{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:23:02Z","timestamp":1765545782572},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,12]],"date-time":"2012-08-12T00:00:00Z","timestamp":1344729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Aureobasidin A (AbA) is a cyclic depsipeptide antifungal compound that inhibits a wide range of pathogenic fungi. In this study, the <jats:italic>in vitro<\/jats:italic> susceptibility of 92 clinical isolates of various <jats:italic>Candida<\/jats:italic> species against AbA was assessed by determining the planktonic and biofilm MICs of the isolates. The MIC<jats:sub>50<\/jats:sub> and MIC<jats:sub>90<\/jats:sub> of the planktonic <jats:italic>Candida<\/jats:italic> yeast were 1 and 1\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup>, respectively, whereas the biofilm MIC<jats:sub>50<\/jats:sub> and MIC<jats:sub>90<\/jats:sub> of the isolates were 8 and \u226564\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup> respectively. This study demonstrates AbA inhibition on filamentation and biofilm development of <jats:italic>C. albicans<\/jats:italic>. The production of short hyphae and a lack of filamentation might have impaired biofilm development of AbA\u2010treated cells. The AbA resistance of mature <jats:italic>Candidia<\/jats:italic> biofilms (24\u2003h adherent population) was demonstrated in this study.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2012.02225.x","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T01:43:21Z","timestamp":1344822201000},"page":"150-156","source":"Crossref","is-referenced-by-count":33,"title":["The inhibitory effects of aureobasidin A on <i>Candida<\/i> planktonic and biofilm cells"],"prefix":"10.1111","volume":"56","author":[{"given":"H. W.","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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