{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:43:49Z","timestamp":1787658229103,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The regular colonisation of the oesophagus with a <jats:italic>Candida<\/jats:italic> species can, after oesophageal perforation, result in a contamination of the mediastinum and the pleura with a <jats:italic>Candida<\/jats:italic> species. A patient cohort of 80 patients with oesophageal perforation between 1986 and 2010 was analysed retrospectively. The most common sources with positive results for <jats:italic>Candida<\/jats:italic> were mediastinal biopsies and broncho\u2010alveolar secretions. <jats:italic>Candida<\/jats:italic> species were detected in 30% of the patients. The mortality rate was 41% in patients with positive microbiology results for <jats:italic>Candida<\/jats:italic>, whereas it was 23% in the remaining patient cohort. This difference did not reach statistical significance (<jats:italic>P<\/jats:italic>\u2003=\u20030.124). Mortality associated with oesophageal perforation was attributed mainly to septic complications, such as mediastinitis and severe pneumonia. During the study period we observed a shift towards non\u2010albicans species that were less susceptible or resistant to fluconazole. In selected patients with risk factors as immunosuppression, granulocytopenia and long\u2010term intensive\u2010care treatment together with the finding of <jats:italic>Candida<\/jats:italic>, an antimycotic therapy should be started. A surgical approach offers the possibility to obtain deep tissue biopsies. The antimycotic therapy should start with an echinocandin, as the resistance to fluconazole is growing and to cover non\u2010albicans <jats:italic>Candida<\/jats:italic> species, too.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2012.02229.x","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T04:51:09Z","timestamp":1345783869000},"page":"173-178","source":"Crossref","is-referenced-by-count":10,"title":["Outcome and management of invasive candidiasis following oesophageal 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