{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:16:39Z","timestamp":1791040599032,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T00:00:00Z","timestamp":1125360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>The present study aimed to investigate the pathogenesis of cystic ovarian disease (COD) in high\u2010yielding dairy cows postpartum (pp). Hormonal and metabolic profiles during the first 3\u2003weeks pp as well as during the final week prior to ovulation\/cyst formation, were compared between dairy cows that developed either an ovulatory follicle (OV) or a cyst (CYST)\u2003&lt;\u2003day 60\u2003pp. Thirty\u2010four lactations of 28 high\u2010yielding (9500\u2003kg\/305\u2003days) Holstein\u2013Friesian dairy cows were studied. Ovaries of cows were scanned twice a week from day 10 pp on, until ovulation\/cyst formation. Milk yield data, body condition scores and blood samples, for determination of oestradiol\u201017<jats:italic>\u03b2<\/jats:italic>, insulin,<jats:italic>\u03b2<\/jats:italic>\u2010OH\u2010butyrate and non\u2010esterified fatty acids, were collected simultaneously. Milk samples for progesterone analysis were collected daily. Four lactations were excluded from further analysis because of irregular pp ovarian cyclicity, excluding COD. Eight lactations (26.7%) developed a cyst, while 22 lactations ovulated &lt;days 60 pp. Ovulation and cyst formation occurred at similar times pp. Metabolic and hormonal profiles did not differ between CYST and OV lactations during the first 3\u2003weeks pp. In the final week prior to cyst formation\/ovulation, insulin concentrations were lower in CYST than in OV lactations while no differences were observed for any of the other parameters tested. In two lactations, cyst formation was preceded by suprabasal progesterone and increased oestradiol\u201017<jats:italic>\u03b2<\/jats:italic>concentrations. These results suggest that cyst formation in high\u2010yielding dairy cows pp is associated with lower insulin levels but not with other distinct hormonal and metabolic alterations. However from this study, we cannot exclude the involvement of subtle hormonal and metabolic changes in the pathogenesis of ovarian cysts. Suprabasal progesterone, and altered oestradiol\u201017<jats:italic>\u03b2<\/jats:italic>concentrations, seem to play a minor role in cyst formation.<\/jats:p>","DOI":"10.1111\/j.1439-0531.2005.00601.x","type":"journal-article","created":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T13:21:25Z","timestamp":1125408085000},"page":"460-467","source":"Crossref","is-referenced-by-count":56,"title":["Hormonal and Metabolic Profiles of High\u2010yielding Dairy Cows Prior to Ovarian Cyst formation or First Ovulation Post 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