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Experiment 1 was carried out on five animals in two phases with a resting period in between. Between \u221248 and 84\u2003h, animals received 12 injections of either saline (CTR) or adrenocorticotrophic hormone (ACTH) agonist (Synacthen; SYN) every 12\u2003h. Cortisol (C), progesterone (P4), oestradiol (E2) and LH were analysed in the blood samples collected every 8\u201312\u2003h between days \u22123 and 4. Pulsatile LH release was studied 4\u2003h before and 4\u2003h after naloxone administration beginning at 96\u2003h. Experiment 2 was carried out on four cows in a cross\u2010over experimental design (two phases, with a resting period in between). Treatments were performed by administering either saline (CTR) or Synacthen (SYN) every 12\u2003h between \u221236 and 24\u2003h. The concentrations of C, P4 and E2 were measured in blood plasma every 4\u201312\u2003h from days \u22123 to 3, then every day from days 5 to 9. In both experiments, ovaries were examined by ultrasonography every 1\u20133\u2003days. ACTH administration induced a significant increase (p\u2003&lt;\u20030.001) of plasma C lasting for 7\u2003days (experiment 1), and for 3\u20134\u2003days (experiment 2). Plasma C returned to baseline levels within 6\u2003days (expt 1) or 36\u2003h (expt 2) after treatment interruption. During the SYN phase, LH pre\u2010ovulatory surge was not detectable. During the CTR phase, naloxone administration induced a significant increase (p\u2003&lt;\u20030.05) of average LH concentrations that was not evident during the SYN phase. The dominant follicle development was retarded and mean plasma E2 concentrations were significantly lower during the SYN phase (p\u2003&lt;\u20030.01). Luteolysis was completed within 2\u2003days. However, P4 decline between 0 and 4\u2003h was slower (p\u2003&lt;\u20030.01) during the SYN phase. Our results indicate that, under prolonged adrenal stimulation, follicular development is delayed and LH release is impaired, which are independent of CL function.<\/jats:p>","DOI":"10.1111\/j.1439-0531.2006.00697.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T01:35:15Z","timestamp":1163640915000},"page":"485-493","source":"Crossref","is-referenced-by-count":12,"title":["Endocrine and Ovarian Responses to Prolonged Adrenal Stimulation at the Time of Induced Corpus Luteum Regression"],"prefix":"10.1111","volume":"41","author":[{"given":"G","family":"Gabai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Badan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.3.651"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(86)90067-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1730211"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(99)80011-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(91)90364-J"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1114"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(97)00026-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(00)00080-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0800025"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1200405"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1250151"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2527\/1997.751249x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(99)00089-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.58.141"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod29.1.11"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(01)74643-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4320(84)90027-7"},{"key":"e_1_2_6_19_1","first-page":"E310","article-title":"Algorithms for the study of episodic hormone secretion","volume":"243","author":"Merriam GR","year":"1982","journal-title":"Am J Physiol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD9910709"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.2003.00500.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.1.1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(02)00161-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.4.921"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-107-2-498"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(00)00196-2"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00652-2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(81)90703-X"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1150015"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00489-1"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0800213"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-2-916"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:9:2:153"},{"key":"e_1_2_6_34_1","volume-title":"SPSS\u00ae 11.0. 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