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Leptin concentrations increased from 16\u2003weeks before puberty to 8\u2003weeks post\u2010puberty and insulin concentrations increased from puberty to 8\u2003weeks post\u2010puberty. Growth hormone concentrations decreased after 4\u2003weeks post\u2010puberty, whereas IGF\u2010I concentrations increased from 8\u2003weeks before puberty to 8\u2003weeks post\u2010puberty. During this period, testicular growth was accelerated and testosterone secretion increased substantially, without any significant changes in gonadotropin secretion. Monthly circulating concentrations of leptin, IGF\u2010I and insulin accounted for 63% of the variation in scrotal circumference and 59% of the variation in paired testes volume. In conclusion, the secretion of metabolic hormones was not associated with changes in gonadotropins concentrations. Furthermore, the associations of leptin, IGF\u2010I and insulin concentrations with testes size indicated that these hormones might be involved in a gonadotropin\u2010independent mechanism regulating the testicular development in peripubertal bulls.<\/jats:p>","DOI":"10.1111\/j.1439-0531.2006.00813.x","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T09:40:08Z","timestamp":1179135608000},"page":"502-508","source":"Crossref","is-referenced-by-count":24,"title":["Circulating Metabolic Hormones During the Peripubertal Period and Their Association with Testicular Development in 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