{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:16:55Z","timestamp":1784305015404,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,7,21]],"date-time":"2007-07-21T00:00:00Z","timestamp":1184976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>The aim of the present study was to demonstrate the presence and localization of MMP\u20102 and \u20109 by means of RT\u2010PCR and immunohistochemistry (IHC) within the canine uterus from the pre\u2010implantation stage until mid\u2010gestation and to determine MMP\u20102 and \u20109 activities by means of zymography. For this purpose, samples of the uterus and salpinx from bitches were obtained after ovariohysterectomy. Pre\u2010implantation stages (5\u201312\u2003days after mating, n\u2003=\u200311) were determined by verifying embryos after flushing the uterus. Further groups were determined as implantation (15\u201319\u2003days after mating, n\u2003=\u20039), post\u2010implantation (20\u201330\u2003days after mating, n\u2003=\u20039) and placental stages (30\u201345\u2003days after mating, n\u2003=\u20033). A non\u2010pregnant group (17\u201330\u2003days after mating, n\u2003=\u20034) served as control. MMP\u20102 and \u20109 positive cells were detected in all specimens from pregnant and nonpregnant bitches, however, with different distributions. MMP\u20102 was present in endothelium and smooth muscles of blood vessels and the myometrium of pregnant and nonpregnant bitches, additionally in the surface epithelium of the oviduct. The latter also stained positive for MMP\u20109. During placentation, MMP\u20102 was detected mainly in fetal blood vessels and trophoblastic cells. Higher MMP\u20102 activity was observed in the endometrium and myometrium of all pregnant groups compared with the nonpregnant group (p\u2003&lt;\u20030.05). The pregnant groups did not differ significantly from each other (p\u2003&gt;\u20030.05). MMP\u20109 was present in blood vessels, smooth muscle cells and epithelia, such as maternal surface epithelial cells, uterine crypts and glands. During placentation, the deep uterine glands and the epithelium of the glandular chambers were immunoreactive to MMP\u20109. Highest MMP\u20109 activities were reached in the endometrium of the pre\u2010implantation group (23.2% of total MMP\u20109) and placental parts (33.3%).<\/jats:p>","DOI":"10.1111\/j.1439-0531.2006.00838.x","type":"journal-article","created":{"date-parts":[[2007,7,21]],"date-time":"2007-07-21T10:17:12Z","timestamp":1185013032000},"page":"654-659","source":"Crossref","is-referenced-by-count":33,"title":["Matrix Metalloproteinase (MMP)\u20102 and MMP\u20109 Activity in the Canine Uterus Before and During Placentation"],"prefix":"10.1111","volume":"42","author":[{"given":"HB","family":"Beceriklisoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sch\u00e4fer\u2010Somi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"\u0130zg\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0460129"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2000.0120"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1230467"},{"key":"e_1_2_7_6_1","first-page":"3","article-title":"Biology and endocrinology of ovulation, pregnancy and parturition in the dog","volume":"39","author":"Concannon PW","year":"1989","journal-title":"J Reprod Fertil Suppl"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.143.8.219"},{"key":"e_1_2_7_8_1","first-page":"554","article-title":"Blood plasma levels of progesterone and oestradiol in the dog during the oestrus cycle and pregnancy","volume":"78","author":"Edqvist LE","year":"1975","journal-title":"Acta Endocrinol (Copenh)"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0867"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.38.24360"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.01.036"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(97)90010-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.11789"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2580463"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/reprod\/118.1.19"},{"key":"e_1_2_7_16_1","volume-title":"Lehrbuch der Embryologie der Haustiere","author":"R\u00fcsse I","year":"1991"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2004.00552.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(94)90833-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.63.401"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2001.0633"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.02.014"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.8.1850705"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod62.1.85"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0531.2006.00838.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0531.2006.00838.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:44:46Z","timestamp":1696949086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0531.2006.00838.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,29]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1439-0531.2006.00838.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0531.2006.00838.x","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,29]]}}}