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This study aimed to determine the effect of sex steroids on the plasma profiles of GH, IGF\u2010I and insulin and their receptors in the liver and adipose tissues of dairy cows. Ovariectomized cows (n\u2003=\u200314) were randomly divided into four groups: control group (n\u2003=\u20033) was treated with saline on Day 0; oestradiol (E2) group (n\u2003=\u20033), with saline and 1\u2003mg oestradiol benzoate (EB) on Day 0 and 5, respectively; progesterone (P4) group (n\u2003=\u20034) with two CIDRs (Pfizer Inc., Tokyo, Japan) from Day 0; and E2\u2003+\u2003P4 group (n\u2003=\u20034) with two CIDRs on Day 0 that were removed on Day 6 and were immediately injected with 1\u2003mg EB. The animals were euthanized after the experiment, and liver and adipose tissues samples were quantitatively analysed using real\u2010time PCR for the expression of mRNA for the GH (GHR), IGF\u2010I (IGFR\u2010I) and insulin (IR) receptor mRNAs. Oestradiol benzoate significantly increased the number of peaks (p\u2003&lt;\u20030.05), pulse amplitude (p\u2003&lt;\u20030.05) and area under the curve (AUC; p\u2003&lt;\u20030.01) for plasma GH; moreover, it increased plasma IGF\u2010I concentration (p\u2003&lt;\u20030.05), but it had no effect on the plasma insulin profile. P4 significantly decreased the AUC (p\u2003&lt;\u20030.01), compared with the control group, whereas it did not affect the number of peaks and the amplitude of GH pulses. P4\u2003+\u2003E2 did not affect the GH pulse profile. E2 increased the mRNA expression of GHR, IGFR\u2010I and IR in the liver (p\u2003&lt;\u20030.05), whereas both P4 and E2\u2003+\u2003P4 did not change their expressions. Our results provide evidence that the metabolic and reproductive endocrine axes may regulate each other to ensure optimal reproductive and metabolic function.<\/jats:p>","DOI":"10.1111\/j.1439-0531.2011.01754.x","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T12:45:25Z","timestamp":1298465125000},"page":"854-861","source":"Crossref","is-referenced-by-count":10,"title":["Oestradiol Enhances Plasma Growth Hormone and Insulin\u2010like Growth Factor\u2010I Concentrations and Increased the Expression of their Receptors mRNAs in the Liver of Ovariectomized 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