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A diagnosis of toxic epidermal necrolysis was made and the treatment was changed to intravenous immunoglobulin at a lower dose than requested. At the height of the reaction, there was 90% body surface area involvement with tri\u2010mucosal involvement. His response to the intravenous immunoglobulin was poor and was complicated by infection with methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Candida albicans<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>. Gradual re\u2010epithelialization took place over the next 6\u2003weeks.<\/jats:p>","DOI":"10.1111\/j.1440-0960.2006.00243.x","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T11:10:26Z","timestamp":1144149026000},"page":"114-116","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Severe toxic epidermal necrolysis precipitated by amphetamine use"],"prefix":"10.1111","volume":"47","author":[{"given":"Hugh","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Rennick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Gin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1996.tb01048.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00549.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_5_5_2","first-page":"548","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Fritsch PO","year":"2003"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0477.2002.02013.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.490"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404990102"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.26"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.39"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02048.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.33"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000124746.33279.86"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198611000-00001"},{"key":"e_1_2_5_16_2","first-page":"273","article-title":"Burn centre care for patients with toxic epidermal necrolysis","volume":"180","author":"Kelemen JJ","year":"1995","journal-title":"J. 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