{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:17:05Z","timestamp":1697530625211},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold>  <jats:italic>To report the initial 18\u2003months experience of the first multi\u2010disciplinary regional Pulmonary Arterial Hypertension (PAH) Clinic in Australia.<\/jats:italic> <\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold>  <jats:italic>Prospective cohort study.<\/jats:italic> <\/jats:p><jats:p><jats:bold>Setting:\u2002<\/jats:bold>  <jats:italic>Community setting on the mid\u2010north coast of New South Wales.<\/jats:italic> <\/jats:p><jats:p><jats:bold>Participants:\u2002<\/jats:bold>  <jats:italic>A total of 47 patients (mean age\u2003<\/jats:italic>\u00b1<jats:italic>\u2003standard error of the mean: 71.8\u2003<\/jats:italic>\u00b1<jats:italic>\u20031.8\u2003years; male\/female ratio 13\/34).<\/jats:italic><\/jats:p><jats:p><jats:bold>Main outcome measures:\u2002<\/jats:bold>  <jats:italic>Diagnosis of PAH, exclusion of other causes of pulmonary hypertension, commencement of PAH\u2010specific pharmacotherapy.<\/jats:italic> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>Twenty\u2010three (49%) patients were discharged back to their GP with pulmonary hypertension from a combination of ischaemic heart and\/or lung disease. Three (6%) patients died from connective tissue disease (CTD)\u2010related PAH with one death (2%) from ischaemic heart disease. Five (11%) patients remain on treatment (<\/jats:italic>n\u2003=<jats:italic>\u20032, Bosentan for congenital heart disease\u2010related PAH;<\/jats:italic> n\u2003=<jats:italic>\u20031 Bosentan for CTD\u2010related PAH; and<\/jats:italic> n\u2003=<jats:italic>\u20031 Bosentan and<\/jats:italic> n\u2003=<jats:italic>\u20031 Sildenafil for primary PAH). Fifteen (32%) patients have ongoing review for PAH related to CTD (<\/jats:italic>n\u2003=<jats:italic>\u200311), carcinoid (<\/jats:italic>n\u2003=<jats:italic>\u20031) and uncertain cause (<\/jats:italic>n\u2003=<jats:italic>\u20033).<\/jats:italic><\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:italic>Patients with CTD\u2010related PAH have a poor prognosis. PAH should be considered in anyone with dyspnoea without obvious features of cardiac or pulmonary disease, especially in the setting of a CTD. Regional population centres are under\u2010resourced with PAH specialty medical services. We have sought to address this by establishment of the first regional multi\u2010disciplinary PAH Clinic in Australia.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1440-1584.2011.01189.x","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T12:09:25Z","timestamp":1301054965000},"page":"89-94","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The initial 18\u2003months of the first multi\u2010disciplinary regional Pulmonary Arterial Hypertension Clinic in Australia"],"prefix":"10.1111","volume":"19","author":[{"given":"Hanish","family":"Bagga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.W.","family":"Chia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn","family":"Hales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Kotlyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeen","family":"Mudholkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Tulk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon H.","family":"Waites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.09.014"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21433"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10775"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1_suppl.14S"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2104059"},{"key":"e_1_2_6_8_2","unstructured":"Pfizer Press Release. [Cited 22 Feb 2011]. Available from URL:http:\/\/www.pfizer.com\/news\/press_releases\/pfizer_press_release_archive.jsp#guid=22387&source=RSS_2010&page=1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.048967"},{"key":"e_1_2_6_10_2","article-title":"The Bosentan Patient Registry: long\u2010term survival in pulmonary arterial hypertension","author":"Keogh A","journal-title":"Internal Medicine Journal"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.742510"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200307-957OC"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050010"},{"key":"e_1_2_6_14_2","first-page":"2417","article-title":"Sildenafil for pulmonary arterial hypertension associated with connective tissue disease","volume":"34","author":"Badesch DB","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_6_15_2","first-page":"783","article-title":"The six\u2010minute walk test","volume":"48","author":"Enright PL","year":"2003","journal-title":"Respiratory Care"},{"key":"e_1_2_6_16_2","unstructured":"Australian Government Department of Health and Ageing.Pharmaceutical Benefits Scheme (PBS). [Cited 22 Feb 2011]. Available from URL:http:\/\/www.pbs.gov.au"},{"key":"e_1_2_6_17_2","unstructured":"Australian Government Medicare Australia.Physician's guide. [Cited 22 Feb 2011]. Available from URL:http:\/\/www.medicareaustralia.gov.au\/provider\/pbs\/drugs2\/files\/2293\u2010physicians\u2010guide.pdf"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-6-200003210-00002"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020204"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-358OC"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-8-200810210-00004"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.618397"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1088"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.2.344"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22069"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2007.01370.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.069484"}],"container-title":["Australian Journal of Rural Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1584.2011.01189.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1584.2011.01189.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:16:25Z","timestamp":1697454985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1584.2011.01189.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,25]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1111\/j.1440-1584.2011.01189.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1584.2011.01189.x","archive":["Portico"],"relation":{},"ISSN":["1038-5282","1440-1584"],"issn-type":[{"value":"1038-5282","type":"print"},{"value":"1440-1584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,25]]},"assertion":[{"value":"2011-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}