{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:48:51Z","timestamp":1773773331268,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T00:00:00Z","timestamp":1143417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Radiology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this paper is the retrospective comparison of accelerated\/hypofractionated radiotherapy regimen (AHFX) with standard fractionation regimen (SFX) for patients with early glottic carcinoma. One hundred and forty\u2010five patients with T<jats:sub>1<\/jats:sub>\u2013T<jats:sub>2<\/jats:sub> glottic cancer between 1986 and 1998 were eligible. Before 1992, patients received 60\u201366\u2003Gy in 30\u201333 fractions over 6\u20136.5\u2003weeks (SFX) with <jats:sup>60<\/jats:sup>Co and 6\u2010MV beams. After 1992, patients received 52.5\u201355\u2003Gy in 20 fractions over 4\u2003weeks (AHFX) using 6\u2010MV beams. The end\u2010points were overall survival, laryngectomy\u2010free survival (LFS), loco\u2010regional control and toxicity. One hundred and two were stage T<jats:sub>1<\/jats:sub>N<jats:sub>0<\/jats:sub>; 43 were stage T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub>. Median follow up was 4.9\u2003years. The 5\u2010year overall survival was 78%. Five\u2010year loco\u2010regional control in T<jats:sub>1<\/jats:sub>N<jats:sub>0<\/jats:sub> patients was higher in AHFX than in SFX group (95 vs 75%, <jats:italic>P<\/jats:italic>\u2003=\u20030.002). Loco\u2010regional control in T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub> patients was similar for AHFX and SFX (81 vs 80%, <jats:italic>P<\/jats:italic>\u2003=\u20030.813). Overall LFS was 88%. T<jats:sub>1<\/jats:sub>N<jats:sub>0<\/jats:sub> AHFX patients had 5\u2010year LFS of 95% compared with 75% for SFX (<jats:italic>P<\/jats:italic>\u2003=\u20030.003). For T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub> AHFX patients, overall LFS was 92% compared with 80% for the SFX group (<jats:italic>P<\/jats:italic>\u2003=\u20030.291). No grade 4 or 5 late toxicity occurred. One AHFX patient developed grade 3 toxicity; two of 51 SFX patients developed grade 2 toxicity versus five of 94 AHFX patients. AHFX using 6\u2010MV beams for treatment of early glottic cancer resulted in equivalent LFS and toxicity when compared with SFX.<\/jats:p>","DOI":"10.1111\/j.1440-1673.2006.01559.x","type":"journal-article","created":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T11:59:30Z","timestamp":1143460770000},"page":"152-157","source":"Crossref","is-referenced-by-count":22,"title":["T<sub>1<\/sub>N<sub>0<\/sub>\/T<sub>2<\/sub>N<sub>0<\/sub> glottic carcinoma: A comparison of two fractionation 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