{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:40:55Z","timestamp":1775522455315,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,11,25]],"date-time":"2004-11-25T00:00:00Z","timestamp":1101340800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>1.\u2002A study performed &gt;\u00a010 years ago and case reports published recently suggest that triclabendazole is effective for the treatment of patients with fascioliasis.<\/jats:p><jats:p>2.\u2002To confirm the efficacy of a human formulation of triclabendazole, we enrolled 165 patients into the present study and divided the subjects into two groups: (i) those who had fascioliasis, as evidenced by the presence of ova in their stools; and (ii) patients with clinical and laboratory data suggesting fascioliasis.<\/jats:p><jats:p>3.\u2002Patients were randomly allocated to receive 10\u00a0mg\/kg, p.o., triclabendazole for 1, 2 or 3 days (single\u2010, double\u2010 and triple\u2010dose groups, respectively). Medical history and physical and laboratory examinations were performed at baseline and at 7, 14, 30 and 60 days after treatment. Results were based on 152 patients who completed the study.<\/jats:p><jats:p>4.\u2002A sharp decrease in the proportion of clinical signs and symptoms was observed in all groups immediately after treatment. Ova disappeared from the stools of all patients in the single\u2010 and double\u2010dose groups. Thirty days after treatment, ova were identified in the stools of two patients in the triple\u2010dose group who received a second course of triclabendazole.<\/jats:p><jats:p>5.\u2002All cases were cured on day 60. However, the cure rate was lower when the patients with suggestive fascioliasis were included in the analysis. The cure rate was not significantly different (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) among the three dose groups. No cases of toxic hepatitis were observed.<\/jats:p><jats:p>6.\u2002In conclusion, oral administration of 10\u00a0mg\/kg of the human pharmaceutical preparation of triclabendazole for 1\u20133 days is safe and effective in the treatment of human fascioliasis.<\/jats:p>","DOI":"10.1111\/j.1440-1681.2004.04093.x","type":"journal-article","created":{"date-parts":[[2004,11,25]],"date-time":"2004-11-25T10:07:24Z","timestamp":1101377244000},"page":"777-782","source":"Crossref","is-referenced-by-count":43,"title":["RANDOMIZED TRIAL OF A SINGLE, DOUBLE AND TRIPLE DOSE OF 10\u00a0MG\/KG OF A HUMAN FORMULATION OF TRICLABENDAZOLE IN PATIENTS WITH FASCIOLIASIS"],"prefix":"10.1111","volume":"31","author":[{"given":"Haleh","family":"Talaie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Emami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davood","family":"Yadegarinia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A","family":"Nava\u2010Ocampo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jafar","family":"Massoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Azmoudeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Mas\u2010Coma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(94)90111-2"},{"key":"e_1_2_6_3_2","first-page":"145","article-title":"Human liver flukes: A review","volume":"57","author":"Mas\u2010Coma S","year":"1997","journal-title":"Res. 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