{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:18:00Z","timestamp":1697001480393},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Chronic renal failure (CRF) is associated with the abnormal regulation of nitric oxide (NO) synthesis at the systemic level. The transport of <jats:sc>l<\/jats:sc>\u2010arginine, upregulated in blood cells from uraemic patients, modulates NO synthesis in this pathological condition. The model of partial nephrectomy in rats is widely accepted as a valid model of uraemia. Because there are no reports of <jats:sc>l<\/jats:sc>\u2010arginine transport in blood cells from uraemic rats, the aim of the present study was to investigate <jats:sc>l<\/jats:sc>\u2010arginine transport in red blood cells (RBCs) from these rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The kinetics of <jats:sc>l<\/jats:sc>\u2010arginine transport in RBC and plasma and the amino acid profiles of RBC were investigated in control, sham\u2010operated and subtotally nephrectomized rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p> <jats:sc>l<\/jats:sc>\u2010Arginine transport was mediated via the cationic amino acid transport system y<jats:sup>+<\/jats:sup> and a transport system with kinetics resembling the human system y<jats:sup>+<\/jats:sup>L. In control RBC, the apparent K<jats:sub>i<\/jats:sub> for <jats:sc>l<\/jats:sc>\u2010leucine inhibition of <jats:sc>l<\/jats:sc>\u2010arginine transport via system y<jats:sup>+<\/jats:sup>L was 0.16\u00a0\u00b1\u00a00.02 and 4.8\u00a0\u00b1\u00a02\u00a0mmol\/L in the presence of Li<jats:sup>+<\/jats:sup> and Na<jats:sup>+<\/jats:sup>, respectively.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The V<jats:sub>max<\/jats:sub> values for <jats:sc>l<\/jats:sc>\u2010arginine transport via system y<jats:sup>+<\/jats:sup>L and system y<jats:sup>+<\/jats:sup> were similar in RBC from control sham\u2010operated and uraemic rats. Moreover, <jats:sc>l<\/jats:sc>\u2010arginine concentrations in plasma and RBC were not affected by uraemia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The findings of the present study provide the first evidence that <jats:sc>l<\/jats:sc>\u2010arginine transport in rat erythrocytes is mediated by two distinct cationic transport systems with characteristics of systems y<jats:sup>+<\/jats:sup> and y<jats:sup>+<\/jats:sup>L, which accept neutral amino acids only in the presence of Li<jats:sup>+<\/jats:sup>. In contrast with previous studies in uraemic patients, plasma levels and maximal transport rates of <jats:sc>l<\/jats:sc>\u2010arginine were not altered in this rat model of CRF.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1440-1681.2006.04421.x","type":"journal-article","created":{"date-parts":[[2010,9,13]],"date-time":"2010-09-13T15:55:39Z","timestamp":1284393339000},"page":"702-707","source":"Crossref","is-referenced-by-count":2,"title":["CHARACTERIZATION OF CATIONIC AMINO ACID TRANSPORT SYSTEMS IN RAT ERYTHROCYTES: LACK OF EFFECT OF URAEMIA ON <scp>l<\/scp>\u2010ARGININE INFLUX"],"prefix":"10.1111","volume":"33","author":[{"given":"TMC","family":"Brunini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MM","family":"Yaqoob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NB","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JC","family":"Ellory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MB","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAS","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GE","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AC","family":"Mendes Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2001.tb01148.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<244::AID-PATH575>3.0.CO;2-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.135"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.36.389"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.29916"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.264"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00267-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000057479"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567270052774403"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"S2791","DOI":"10.1093\/jn\/134.10.2791S","article-title":"Renal arginine metabolism","volume":"134","author":"Brosnan ME","year":"2004","journal-title":"J. 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