{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:07:01Z","timestamp":1769771221038,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,10]],"date-time":"2006-08-10T00:00:00Z","timestamp":1155168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Pre\u2010eclampsia is a serious complication of pregnancy that is potentially life threatening for both the mother and baby. It encompasses a number of abnormalities that may be present in other clinical conditions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A placenta is essential for the development of pre\u2010eclampsia and can be important in the pathogenesis of pre\u2010eclampsia. Normal pregnancy is associated with remodelling of the maternal spiral arteries, which deliver blood to the placental villous space. Remodelling involves invasion by placental cytotrophoblasts that cause the maternal spiral arteries to lose their smooth muscle and become capacitance vessels; this process, known as placentation, is complete by 20 weeks of pregnancy. Poor placentation is associated with small\u2010for\u2010gestational\u2010age fetuses and some cases of pre\u2010eclampsia. It is thought that poor placentation can result in a hypoxic placenta that releases \u2018toxic substances\u2019 into the maternal circulation, contributing to the maternal syndrome. A number of candidate \u2018toxic substances\u2019 have been proposed, but none is universally raised in pre\u2010eclampsia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Although the placenta is necessary for the development of pre\u2010eclampsia, the extent to which placental abnormalities contribute to the condition varies. It is becoming apparent that maternal constitutional factors may also be important in this syndrome. Underlying hypertension, diabetes and obesity strongly predispose to pre\u2010eclampsia. However, a continuum of risk may exist for blood pressure, bodyweight, glucose and lipids, which, in combination with each other and some degree of placental abnormalities, may lead to the development of pre\u2010eclampsia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The present review will focus on the maternal constitutional factors that define the metabolic syndrome and examine their contribution to pre\u2010eclampsia and the long\u2010term consequences for cardiovascular health.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1440-1681.2006.04448.x","type":"journal-article","created":{"date-parts":[[2006,8,10]],"date-time":"2006-08-10T09:54:15Z","timestamp":1155203655000},"page":"826-830","source":"Crossref","is-referenced-by-count":29,"title":["PRE\u2010ECLAMPSIA: CONTRIBUTION OF MATERNAL CONSTITUTIONAL FACTORS AND THE CONSEQUENCES FOR CARDIOVASCULAR HEALTH"],"prefix":"10.1111","volume":"33","author":[{"given":"Anne","family":"Barden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,10]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2000.tb01136.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(91)90339-H"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.07.005"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15114.x"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.EDE.0000059921.71494.D1"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.91.3.436"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917090-00011"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470020063033"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200412000-00020"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90347-4"},{"key":"e_1_2_11_13_2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/ajh\/7.10.933","article-title":"Postpartum blood pressure and insulin sensitivity in African\u2010American women with recent pre\u2010eclampsia","volume":"7","author":"Jacober SJ","year":"1994","journal-title":"Am. 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