{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:49:23Z","timestamp":1770824963010,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T00:00:00Z","timestamp":1159228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The present study was performed to investigate the hepatoprotective and hypolipidaemic effects of a 27\u00a0kDa glycoprotein isolated from <jats:italic>Gardenia jasminoides<\/jats:italic> Ellis (GJE glycoprotein) in glucose\/glucose oxidase (G\/GO)\u2010treated BNL\u00a0CL.2 cells, as well as in CCl<jats:sub>4<\/jats:sub>, Triton WR\u20101339 and corn oil\u2010treated mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In G\/GO\u2010treated BNL\u00a0CL.2 cells, the results showed that GJE glycoprotein has an inhibitory effect on G\/GO\u2010induced cytotoxicity and intracellular reactive oxygen species production. In addition, GJE glycoprotein has an anti\u2010oxidant effect against the lipid peroxidation process in the Fe<jats:sup>2+<\/jats:sup>\/ascorbic acid system.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In CCl<jats:sub>4<\/jats:sub> (1.0\u00a0mL\/kg)\u2010treated mice, pretreatment with GJE glycoprotein (80\u00a0mg\/kg) blocked lactate dehydrogenase release and the formation of thiobarbituric acid\u2010reactive substances. In addition, in these mice GJE resulted in increased nitric oxide production and the activation of anti\u2010oxidant enzymes, accompanied by the inhibition of the cytotoxic\u2010related signals hepatic cytochrome <jats:italic>c<\/jats:italic>, nuclear factor\u2010\u03baB and activator protein\u20101.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In both Triton WR\u20101339 (400\u00a0mg\/kg) and corn oil (1.0\u00a0g\/kg)\u2010treated mice, pretreatment with GJE glycoprotein (80\u00a0mg\/kg) lowered the levels of plasma lipoproteins (triglyceride, total cholesterol and low\u2010density lipoprotein).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>On the basis of these results, we assume that GJE glycoprotein can ameliorate liver function, because it has hepatoprotective and hypolipidaemic activities.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1440-1681.2006.04466.x","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T12:44:11Z","timestamp":1159274651000},"page":"925-933","source":"Crossref","is-referenced-by-count":31,"title":["HEPATOPROTECTIVE AND HYPOLIPIDAEMIC EFFECTS OF GLYCOPROTEIN ISOLATED FROM <i>GARDENIA JASMINOIDES<\/i> ELLIS IN MICE"],"prefix":"10.1111","volume":"33","author":[{"given":"Sei\u2010Jung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil\u2010Sun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye\u2010Taek","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)32099-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107332"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(89)90050-8"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040483"},{"key":"e_1_2_6_6_2","first-page":"443","article-title":"Reaction of glutathione with a free radical metabolite of carbon tetrachloride","volume":"37","author":"Connor HD","year":"1990","journal-title":"Mol. 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