{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:01:30Z","timestamp":1780066890575,"version":"3.54.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T00:00:00Z","timestamp":1159228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Chronic hyperglycaemia in diabetes leads to the overproduction of free radicals and evidence is increasing that these contribute to the development of diabetic nephropathy. Among the spices, turmeric (<jats:italic>Curcuma longa<\/jats:italic>) is used as a flavouring and colouring agent in the indian diet every day and is known to possess anti\u2010oxidant properties. The present study was designed to examine the effect of curcumin, a yellow pigment of turmeric, on renal function and oxidative stress in streptozotocin (STZ)\u2010induced diabetic rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Diabetes was induced by a single intraperitoneal injection of STZ (65\u00a0mg\/kg) in rats. Four weeks after STZ injection, rats were divided into four groups, namely control rats, diabetic rats and diabetic rats treated with curcumin (15 and 30\u00a0mg\/kg, p.o.) for 2 weeks. Renal function was assessed by creatinine, blood urea nitrogen, creatinine and urea clearance and urine albumin excretion. Oxidative stress was measured by renal malonaldehyde, reduced glutathione and the anti\u2010oxidant enzymes superoxide dismutase and catalase.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Streptozotocin\u2010injected rats showed significant increases in blood glucose, polyuria and a decrease in bodyweight compared with age\u2010matched control rats. After 6 weeks, diabetic rats also exhibited renal dysfunction, as evidenced by reduced creatinine and urea clearance and proteinuria, along with a marked increase in oxidative stress, as determined by lipid peroxidation and activities of key anti\u2010oxidant enzymes. Chronic treatment with curcumin significantly attenuated both renal dysfunction and oxidative stress in diabetic rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results provide confirmatory evidence of oxidative stress in diabetic nephropathy and point towards the possible anti\u2010oxidative mechanism being responsible for the nephroprotective action of curcumin.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1440-1681.2006.04468.x","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T12:44:11Z","timestamp":1159274651000},"page":"940-945","source":"Crossref","is-referenced-by-count":253,"title":["CURCUMIN, THE ACTIVE PRINCIPLE OF TURMERIC (<i>CURCUMA LONGA<\/i>), AMELIORATES DIABETIC NEPHROPATHY IN RATS"],"prefix":"10.1111","volume":"33","author":[{"given":"Sameer","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivas K","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanwaljit","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(99)00044-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.11.1433"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00365519950185823","article-title":"Lipid peroxidation and antioxidant enzyme activities in patients with type\u2010I diabetes mellitus","volume":"59","author":"Ruiz C","year":"1994","journal-title":"Scand. 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