{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:15:58Z","timestamp":1761016558918},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Diabetic neuropathy is a many faceted complication of both type I and II diabetes. The aim of the present study was to investigate the effects of bendazac lysine (BDL), an anticataract drug, on experimental diabetic peripheral neuropathy (DPN) in rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Diabetes was induced in rats by intraperitoneal injection of 75\u00a0mg\/kg streptozotocin (STZ) dissolved in 0.1\u00a0mol\/L citrate buffer (pH\u00a04.4). Bendazac lysine was administered to rats at doses of 50, 100 and 200\u00a0mg\/kg twice a day for 12 weeks.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Diabetic rats without treatment showed hypopraxia, polydipsia, polyuria, slow weight gain, cataract, increased tail\u2010flick threshold temperature, decreased motor nerve conduction velocity (nd induced pathological morphological changes of myelinated nerve fibres. All these symptoms were ameliorated in diabetic rats treated with BDL. Bendazac lysine ameliorated the blood glucose concentration, glycosylated haemoglobin levels and insulin levels in the plasma of diabetic rats, reduced aldose reductase activity in erythrocytes and advanced glycation end\u2010products in both nerves and serum and increase the activity of glutathione peroxidase in the nerves and Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase in the nerves and erythrocytes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Bendazac lysine exerts its protective effects against the progression of diabetic peripheral neuropathy in STZ\u2010diabetic rats through multiple mechanisms and is a potential drug for the prevention of deterioration in DPN.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/j.1440-1681.2006.04515.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T06:06:14Z","timestamp":1166681174000},"page":"1231-1238","source":"Crossref","is-referenced-by-count":11,"title":["PROTECTIVE EFFECTS OF BENDAZAC LYSINE ON DIABETIC PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN\u2010INDUCED DIABETIC RATS"],"prefix":"10.1111","volume":"33","author":[{"given":"Jun\u2010Xian","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin\u2010Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Xing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Ping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Lin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/EDR.2003.271"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-8-199504150-00001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050674"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0311423"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(95)01071-K"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/15438600490424514"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.8.2110"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1986.tb00774.x"},{"key":"e_1_2_5_10_2","first-page":"126","article-title":"Use of bendazac lysine to limit protein deposition on soft contact lenses in vitro","volume":"17","author":"Missiroli A","year":"1991","journal-title":"CLAO J."},{"key":"e_1_2_5_11_2","first-page":"819","article-title":"Studies on the activity of Bendalina (bendazac l\u2010lysine salt) as a scavenger of hydroxyl and superoxide radicals","volume":"97","author":"Schmut O","year":"1985","journal-title":"Wien Klin. 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