{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:07:54Z","timestamp":1782529674851,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T00:00:00Z","timestamp":1172188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:list list-type=\"explicit-label\"><jats:list-item><jats:p>In the present study, we investigated the role of endothelin ET<jats:sub>B<\/jats:sub>receptors in gender differences in the development of deoxycorticosterone acetate (DOCA)\u2010salt\u2010induced hypertension by using the spotting\u2010lethal (<jats:italic>sl<\/jats:italic>) rat, which carries a naturally occurring deletion in the ET<jats:sub>B<\/jats:sub>receptor gene.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In wild\u2010type rats, the elevation of systolic blood pressure (SBP) by DOCA\u2010salt treatment for 4 weeks was extremely lower in females than in males, but this gender difference was partially attenuated in ovariectomized (OVX) animals. These alterations of SBP corresponded with vascular superoxide (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/CEP_4580_mu1.gif\" xlink:title=\"inline image\"\/>) production.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In homozygous (<jats:italic>sl\/sl<\/jats:italic>) group, the SBP of male, intact female and OVX rats was markedly elevated by DOCA\u2010salt treatment to the same extent, indicating that the gender difference in DOCA\u2010salt\u2010induced hypertension was abolished by the genetic ET<jats:sub>B<\/jats:sub>receptor deficiency. There were similar increases in the vascular endothelin (ET)\u20101 content in the three DOCA\u2010salt\u2010treated animal groups, but vascular<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/CEP_4580_mu1.gif\" xlink:title=\"inline image\"\/>production in male and OVX rats was much higher than that in intact females.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Daily oral administration of ABT\u2010627, an ET<jats:sub>A<\/jats:sub>receptor antagonist, to<jats:italic>sl\/sl<\/jats:italic>rats for 2 weeks suppressed the DOCA\u2010salt\u2010induced hypertension more efficiently in intact female rats than in male animals.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Thus, vascular oxidative stress is related, at least in part, to differences in the development of DOCA\u2010salt\u2010induced hypertension between male and female rats, but this gender difference is abolished by the genetic ET<jats:sub>B<\/jats:sub>receptor deficiency, suggesting that ET<jats:sub>B<\/jats:sub>receptor\u2010mediated vasoprotective actions contribute to the gender differences seen. In addition, in both sexes, vascular ET\u20101 overproduction and the ET<jats:sub>A<\/jats:sub>receptor\u2010mediated action seem to be responsible for the enhanced susceptibility to DOCA\u2010salt hypertension in genetic ET<jats:sub>B<\/jats:sub>receptor deficiency.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1111\/j.1440-1681.2007.04580.x","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T16:52:17Z","timestamp":1282236737000},"page":"280-285","source":"Crossref","is-referenced-by-count":35,"title":["INVOLVEMENT OF THE ENDOTHELIN ET<sub>B<\/sub>RECEPTOR IN GENDER DIFFERENCES IN DEOXYCORTICOSTERONE ACETATE\u2010SALT\u2010INDUCED HYPERTENSION"],"prefix":"10.1111","volume":"34","author":[{"given":"Hideaki","family":"Kawanishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Ohkita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Takaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.72.261"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/348730a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/348732a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.4.876"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13292.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.397"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)96213-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.70.313"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.2.183"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.1.R245"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.2.759"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.22.2765"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.1.494"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703389"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.3.692"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000142893.08655.96"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3702"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8609"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0022-3565(25)12297-0","article-title":"Pharmacological characterization of A\u2010127722: An orally active and highly potent ETA\u2010selective receptor antagonist","volume":"276","author":"Opgenorth TJ","year":"1996","journal-title":"J. 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