{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:33:50Z","timestamp":1762605230034,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cancer Council of Tasmania"},{"DOI":"10.13039\/100012503","name":"Royal Hobart Hospital Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012503","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Australia has the highest incidence of skin cancer in the world and ultraviolet (UV)\u2010B radiation has been implicated as its major aetiological agent. Despite the link between melanoma and exposure to UV\u2010B radiation in childhood, little work has been carried out to determine the effects of UV\u2010B on neonatal skin. In this study, we investigated the response of adult and neonatal Langerhans cells (LC) to UV\u2010B radiation to determine whether exposure in the neonatal period impairs the development of the skin immune system, thus having implications for the immune response later in life. Neonatal and adult mice were irradiated with a single dose of UV\u2010B radiation and epidermal sheets prepared to determine the number of LC present. In addition, antigen carriage and T\u2010cell proliferation assays were carried out to assess the immune response when the mice reached maturity. Results showed that neonatal LC were more susceptible than adult LC to depletion at 2 kJ\/m<jats:sup>2<\/jats:sup> UV\u2010B exposure; however, there was similar susceptibility at lower doses. When mice that were irradiated as neonates were analysed at maturity, there was an increased ability to respond to cutaneously applied antigen as more antigen was transported to the lymph node and the lymph node dendritic cells had an enhanced ability to stimulate T\u2010cell proliferation. In addition, this response was skewed towards a Th2 type response. Thus, single high\u2010dose UV\u2010B exposure alters the development of neonatal LC, resulting in a short\u2010term reduction in the number of LC but an enhanced immune response when assessed at maturity.<\/jats:p>","DOI":"10.1111\/j.1440-1711.2006.01429.x","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T15:28:48Z","timestamp":1140708528000},"page":"259-266","source":"Crossref","is-referenced-by-count":7,"title":["Neonatal exposure to UV\u2010B radiation leads to a large reduction in Langerhans cell density, but by maturity, there is an enhanced ability of dendritic cells to stimulate T cells"],"prefix":"10.1111","volume":"84","author":[{"given":"Heather M","family":"McGee","sequence":"first","affiliation":[{"name":"Immunology and Cancer Research Group, School of Medicine, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah K","family":"Scott","sequence":"additional","affiliation":[{"name":"Immunology and Cancer Research Group, School of Medicine, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M","family":"Woods","sequence":"additional","affiliation":[{"name":"Immunology and Cancer Research Group, School of Medicine, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1963.35"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.5.1333"},{"key":"e_1_2_7_4_1","first-page":"445","article-title":"Immunologic responses of the autochthonous host against tumors induced by ultraviolet light","volume":"66","author":"Kripke ML","year":"1976","journal-title":"Adv. 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Induction of specific clonal anergy in CD4+ T helper 1 cells","volume":"146","author":"Simon JC","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_7_11_1","first-page":"205","article-title":"Antigen presentation in the skin: modulation by u.v. radiation and chemical carcinogens","volume":"4","author":"Muller HK","year":"1992","journal-title":"Semin. 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