{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:40:13Z","timestamp":1790887213411,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Severe stress decreases the resistance of hosts exposed to microbial infections. As compared with two groups of control mice (normal mice, food\u2010and\u2010water\u2010deprived mice [FWD mice]), restraint\u2010stressed mice (RST mice) were shown to be greatly susceptible to intracerebral growth of <jats:italic>Cryptococcus neoformans<\/jats:italic>. The susceptibility of FWD mice to cerebral cryptococcosis increased to the level shown in RST mice, when these groups of mice were inoculated with microglial cells from the brains of RST mice. However, the susceptibility of FWD mice to cerebral cryptococcosis was not influenced by the adoptive transfer of microglial cells from normal mice or FWD mice. Microglial cells from RST mice produced CC\u2010chemokine ligand\u20102 (CCL\u20102\/monocyte chemoattractant protein 1), but not microglial cells from FWD mice. The resistance of RST mice to cerebral cryptococcosis was improved to the extent shown in FWD mice, when they were treated with anti\u2010CCL\u20102 antibody. However, the susceptibility of normal mice and FWD mice to cerebral cryptococcosis increased to that shown in RST mice, when they were treated with rCCL\u20102. Microglial cells from RST mice were discriminated from the same cell preparations derived from FWD mice by their abilities to produce CCL\u20102, to phagocytize <jats:italic>C. neoformans<\/jats:italic> cells and to express Toll\u2010like receptor 2. These results indicate that the resistance of RST mice to cerebral cryptococcosis is diminished by CCL\u20102 produced by microglial cells that are influenced by restraint stress.<\/jats:p>","DOI":"10.1111\/j.1440-1711.2006.01466.x","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T08:13:14Z","timestamp":1157443994000},"page":"551-556","source":"Crossref","is-referenced-by-count":13,"title":["Microglial cells from psychologically stressed mice as an accelerator of cerebral cryptococcosis"],"prefix":"10.1111","volume":"84","author":[{"given":"Masae","family":"Shimoda","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie C","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.7231"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.24.2268"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.2000.0598"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00266-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00273-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.2000.0619"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.2001.0624"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(03)00026-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1998.0521"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2001.01005.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1106"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10161"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.6.1163"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200207000-00003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(02)00021-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(02)00060-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304040-00004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1998.0685"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs0202.103399"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.70.3.374"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.6.1190"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00079-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00174-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(20010101)33:1<87::AID-GLIA1008>3.0.CO;2-S"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(94)00076-F"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a002969"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00319-2"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.941"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1557"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)82906-X"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/35006097"}],"container-title":["Immunology &amp; 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