{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:34:09Z","timestamp":1774794849956,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T00:00:00Z","timestamp":1251244800000},"content-version":"vor","delay-in-days":4196,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p>The possession of the cytotoxin\u2010associated gene (<jats:italic>cagA<\/jats:italic>) of <jats:italic>Helicobacter pylori<\/jats:italic> is thought to be highly associated with peptic ulcer disease. However, the pathogenic role of <jats:italic>cagA<\/jats:italic> is still unknown. We have emphasized the importance of the interrelationship between <jats:italic>H. pylori<\/jats:italic>\u2010derived ammonia and oxygen radicals from in\ufb01ltrated leucocytes. The aim of the present study was to explore the relationship between oxygen radical production and <jats:italic>H. pylori<\/jats:italic> strain diversity based on <jats:italic>cagA<\/jats:italic> possession. An endoscopic examination and gastric mucosal biopsy were performed in 30 <jats:italic>H. pylori\u2010<\/jats:italic>infected patients with gastric ulcer. Myeloperoxidase (MPO) content and the luminol\u2010dependent chemiluminescence value in the biopsied gastric specimens were measured as an index for leucocyte in\ufb01ltration and oxygen radical production. From the precipitates of cultured bacterial isolates of biopsied specimens, bacterial DNA was puri\ufb01ed and analysed by polymerase chain reaction to characterize the possession of <jats:italic>cagA<\/jats:italic>. While all patients had <jats:italic>ureC<\/jats:italic>\u2010positive strains, 22 had <jats:italic>cagA<\/jats:italic>\u2010positive and eight had <jats:italic>cagA<\/jats:italic>\u2010negative strains. In patients with <jats:italic>cagA<\/jats:italic>\u2010positive strains, MPO contents as well as chemiluminescence values in the gastric corpus were signi\ufb01cantly higher than those in patients with <jats:italic>cagA<\/jats:italic>\u2010negative strains. Gastric mucosal leucocyte recruitment and activation are suggested to be enhanced by <jats:italic>cagA<\/jats:italic> gene\u2010positive <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/j.1440-1746.1998.01558.x","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T11:37:43Z","timestamp":1240400263000},"page":"294-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Augmented levels of gastric mucosal leucocyte activation by infection with <i>cagA<\/i> gene\u2010positive <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"13","author":[{"given":"HIDEKAZU","family":"SUZUKI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASAYUKI","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIKIJI","family":"MORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TETSUJI","family":"KITAHORA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROKAZU","family":"YOKOYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOICHIRO","family":"MIURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHIFUMI","family":"HIBI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROMASA","family":"ISHII","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.1994.03520010077036","article-title":"NIH Consensus Conference: Helicobacter pylori in peptic ulcer disease. 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