{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T19:40:19Z","timestamp":1734810019640,"version":"3.32.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:00:00Z","timestamp":1084838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>Hypothyroidism is commonly thought to cause decreased gastric emptying but is mostly associated with autoimmune disease. In the present study the gastric emptying function of thyroid cancer patients with severe hypothyroidism of short duration was evaluated with a radionuclide solid meal gastric emptying study.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>Twenty\u2010two patients who had undergone surgical operation and<jats:sup>131<\/jats:sup>I ablation for thyroid cancer participated in solid meal gastric emptying studies before the withdrawal of thyroxine and then again 4\u2003weeks after the withdrawal of thyroxine. Eleven patients had an additional gastric emptying study at 6\u2003weeks after withdrawal of thyroxine. Gastric emptying curves and emptying parameters were calculated. Student's paired<jats:italic>t<\/jats:italic>\u2010test was used for statistical analysis of data for all cases between the baseline and at 4\u2003weeks after withdrawal. An additional repeated measure<jats:sc>anova<\/jats:sc>with multiple comparisons was performed on data between baseline, 4\u2003weeks and 6\u2003weeks after withdrawal for the other 11 patients. All<jats:italic>P<\/jats:italic>values presented are two\u2010tailed and the significance level is 0.05.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Hypothyroidism status was confirmed by the marked change of the serum thyroxine and thyroid\u2010stimulating hormone 4\u2003weeks and 6\u2003weeks after withdrawal of the thyroxine replacement (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). The gastric half\u2010emptying time and emptying rate changed significantly after short\u2010term severe thyroid hormone deficiency (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005). However, the length of the lag phase did not have a statistically significant change at 4\u2003weeks or 6\u2003weeks after withdrawal of the thyroxin replacement (<jats:italic>P<\/jats:italic>\u2003=\u20030.219 and 0.142).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>Hypothyroidism following the withdrawal of the thyroxine replacement in thyroid cancer patients preparing for<jats:sup>131<\/jats:sup>I cancer work\u2010up can significantly prolong gastric half\u2010emptying time and emptying rate.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2003.03326.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T07:32:17Z","timestamp":1104132737000},"page":"655-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gastric emptying function changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy"],"prefix":"10.1111","volume":"19","author":[{"given":"PAN\u2010FU","family":"KAO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEN\u2010DER","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHENG\u2010TANG","family":"CHIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUI\u2010TING","family":"HSU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAI\u2010CHU","family":"SEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAI\u2010YUAN","family":"TZEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199709000-00014"},{"key":"e_1_2_6_3_2","first-page":"1017","volume-title":"Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text","author":"Sellin RV","year":"1991"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90478-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296214"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00348203"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.1.85"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31472-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02239597"},{"key":"e_1_2_6_10_2","first-page":"198","article-title":"Gastric emptying in hypothyreosis","volume":"33","author":"Jonderko G","year":"1977","journal-title":"Isr. 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