{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:09:51Z","timestamp":1778180991122,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T00:00:00Z","timestamp":1081814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Matrix metalloproteases (MMP) and \u03b1\u2010fetoproteins (AFP) are involved in hepatitis B virus (HBV)\u2010induced chronic hepatitis. In the present study, we have determined the correlation between the MMP\u20109\/MMP\u20109 ratio and AFP levels in the serum of patients during chronic viral B hepatitis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010eight healthy individuals (18 men and 10 women) with a mean age of 36.3 years (range 23\u201358 years) and 50 patients (42 men, 8 women) with a mean age of 39.7 years (range 22\u201361 years) participated in the study. Forty\u2010eight participants had HBV and the remaining two were either hepatitis G virus (HGV) or hepatitis C virus (HCV) carriers. Values of patients were compared with those obtained from 12 blood donor controls (5 men, 7 women), mean age 36 years (range 21\u201346 years). Patient's sera were subjected to examination of hepatitis B surface (HBs) and hepatitis B early (Hbe) antigen, SGOT, SGPT, AFP, MMP\u20102 and MMP\u20109. Serum levels of MMP\u20102 and MMP\u20109 activities were measured by a zymogram protease assay and densitometric measurement. The ratios of MMP\u20109 to MMP\u20102 were calculated by dividing the densitometric results.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with the healthy controls, the mean serum concentrations of MMP\u20102 were slightly increased in the chronic HBV patients. In contrast, compared with the healthy controls, the mean serum concentrations of MMP\u20109 were significantly increased in the chronic HBV patients. When the ratios of the MMP\u20109\/MMP\u20102 and amounts of the serum AFP were compared, a specific correlation between these two parameters was observed. Higher amounts of AFP were detected in the patients with a low ratio of MMP\u20109\/MMP\u20102. Patients with hepatocellular carcinoma (HCC) and cirrhosis showed relatively low MMP\u20109\/MMP\u20102 ratios in chronic hepatitis B. In addition, AFP levels of HCC and cirrhosis were higher than in chronic HBV patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results indicate that the AFP level and ratio of MMP\u20109 and MMP\u20102 is highly correlated in chronic HBV\u2010induced hepatitis. Because the serum MMP activities were significantly varied between each stage of AFP production in liver disease, an individual profile of these parameters might serve as an easy accessing serum marker to monitor the progression of liver disease.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03344.x","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T09:46:31Z","timestamp":1081849591000},"page":"565-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Correlation between plasma levels of matrix metalloproteinase (MMP)\u20109 \/MMP\u20102 ratio and \u03b1\u2010fetoproteins in chronic hepatitis carrying hepatitis B virus"],"prefix":"10.1111","volume":"19","author":[{"given":"TAE\u2010WOOK","family":"CHUNG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEONG\u2010RAN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEONG\u2010IL","family":"SUH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOUNG\u2010CHOON","family":"LEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOUNG\u2010CHAE","family":"CHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAI HO","family":"CHUNG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHEORL\u2010HO","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"726","article-title":"Early recognition of hepatocellular carcinoma","volume":"6","author":"Okada K","year":"1986","journal-title":"Hepatology"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92249-S"},{"key":"e_1_2_6_4_2","first-page":"3453","article-title":"Hepatitis B virus X protein modulates the expression of PTEN by inhibiting the function of p53, transcriptional activator in liver cells","volume":"63","author":"Chung TW","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90770-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007105"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80985-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80423-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/clinchem\/46.2.183","article-title":"Expression of matrix metalloproteinase\u20102 and 9 and their inhibitors in peripheral blood cells of patients with chronic hepatitis C","volume":"46","author":"Lichtinghagen R","year":"2000","journal-title":"Clin. 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