{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:20:39Z","timestamp":1790061639091,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T00:00:00Z","timestamp":1081814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Basic fibroblast growth factor (bFGF) is a key factor in the healing of human and experimental peptic ulcers, but the behavior of bFGF in human giant gastric ulcer remains to be determined. We determined the bFGF content in the rim of giant ulcers (bFGF rim) and in non\u2010ulcerated mucosa located opposite the ulcer (bFGF opposite) before and during treatment.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Biopsy specimens were endoscopically obtained from 31 patients with giant gastric ulcers and 17 patients with small ulcers before and 2, 4 and 8 weeks after treatment. The bFGF concentrations in the specimens were measured using a sandwich enzyme immunoassay.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Before treatment, the bFGF rim and bFGF opposite concentrations were not associated with ulcer size. The bFGF rim concentration before treatment in the rapid healing group was higher than that in the slow healing group, but no significant difference in bFGF opposite concentrations were found between the two groups. The bFGF rim concentration in the rapid healing patients decreased during treatment, while the slow healing patients showed an inverse response. The bFGF opposite concentration did not change during treatment and bFGF rim concentrations in <jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive stomachs were significantly lower than those in <jats:italic>H. pylori<\/jats:italic>\u2010negative stomachs.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The bFGF rim concentration is not involved in the formation of giant gastric ulcers in humans. However, the bFGF rim concentration does appear to promote healing. The bFGF opposite concentration is not related to either the formation or healing of giant gastric ulcers.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03359.x","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T09:46:31Z","timestamp":1081849591000},"page":"528-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mucosal concentration of basic fibroblast growth factor in the healing process in human giant gastric ulcers"],"prefix":"10.1111","volume":"19","author":[{"given":"AKIRA","family":"MIZUKI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAYUKI","family":"TATEMICHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROMI","family":"NISHIYA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUTO","family":"FUKUI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TATSUHIKO","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NOBUHIRO","family":"TSUKADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROSHI","family":"NAGATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROMASA","family":"ISHII","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01665.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018835219474"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198410000-00004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658111"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1996.tb00805.x"},{"key":"e_1_2_6_7_2","first-page":"255","article-title":"Giant gastric ulcers. A review of 49 cases","volume":"203","author":"Thomas PB","year":"1985","journal-title":"Ann. Surg."},{"key":"e_1_2_6_8_2","first-page":"143","article-title":"Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues","volume":"42","author":"Baird A","year":"1986","journal-title":"Recent Prog. Horm. Res."},{"key":"e_1_2_6_9_2","first-page":"832","article-title":"Expression of basic fibroblast growth factor in normal human tissues","volume":"63","author":"Cordon CC","year":"1990","journal-title":"Lab. Invest."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/325257a0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)90614-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.8.2292"},{"key":"e_1_2_6_13_2","first-page":"393","article-title":"A heparin\u2010binding angiogenic protein \u2013 basic fibroblast growth factor is stored within basement membrane","volume":"130","author":"Folkman J","year":"1988","journal-title":"Am. J. Pathol."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.4.525"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.7.881"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90773-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.5.610"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051886"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81224-0"},{"key":"e_1_2_6_20_2","first-page":"200","article-title":"Rapid urease test in the management of Campylobacter pylori disassociated gastritis","volume":"82","author":"Marshall BJ","year":"1987","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/jcm.29.1.51-53.1991","article-title":"Evaluation of techniques for isolation, subcultivation, and preservation of Helicobacter pylori","volume":"29","author":"Ansorg RRG","year":"1991","journal-title":"J. Clin. Microbiol."},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.29.11.2587-2589.1991"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199506002-00002"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.014s1033.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00627.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309098333"},{"key":"e_1_2_6_27_2","first-page":"65","article-title":"Grade of Helicobacter \u200apylori\u200acolonisation \u200ain \u200arelation \u200ato \u200agastritis: \u200aa six\u2010year population\u2010based follow\u2010up study","volume":"186","author":"Kekki M","year":"1991","journal-title":"Scand. J. Gastroenterol. Suppl."}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1746.2004.03359.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1746.2004.03359.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T01:58:27Z","timestamp":1697335107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1746.2004.03359.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,13]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1440-1746.2004.03359.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1746.2004.03359.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,13]]},"assertion":[{"value":"2004-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}