{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:01:04Z","timestamp":1760979664308},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,5,11]],"date-time":"2004-05-11T00:00:00Z","timestamp":1084233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Transanal endoscopic microsurgery (TEM) was a technique developed to allow the excision of adenomas and early\u2010stage cancers from the rectum and distal sigmoid colon. The aim of this project was to prospectively study surgical morbidity, mortality and the local recurrence rate of all patients treated with this technique.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> All patients undergoing TEM were prospectively evaluated. Endpoints to assess the surgical morbidity and mortality were defined before the study commenced. All patients underwent regular follow up to determine treatment efficacy in terms of the local recurrence rate and survival.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The study involved 113 patients, with a mean age of 69\u2003years (standard deviation 14\u2003years, range 30\u201394\u2003years), and a male to female ratio of 1.4:1. The mean polyp area was 20.5\u2003cm<jats:sup>2<\/jats:sup> (range 1\u2013169\u2003cm<jats:sup>2<\/jats:sup>) and the mean height above the anal verge was 9.5\u2003cm (range 4\u201325\u2003cm). Histology of the tumors found 62 adenomas, 20 carcinomas <jats:italic>in situ<\/jats:italic>, and 31 adenocarcinomas. There were no unplanned returns to theater or postoperative deaths. Four patients required readmission within 30\u2003days because of bleeding, and nine patients underwent more radical surgical procedures following histological evaluation of the resected specimens. During a mean follow up of 1.5\u2003\u00b1\u20030.8\u2003years (maximum 3.2\u2003years), there have been two recurrences of villous adenomas. The actuarial local recurrence rate at 2\u2003years is 2.4% (95% confidence interval 0.8\u20134.0%).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> TEM was demonstrated to be a safe surgical procedure, and early follow up has shown it to be an efficacious treatment for benign rectal adenomas and early rectal cancers.<\/jats:p><jats:p>\u00a9 2004 Blackwell Publishing Asia Pty Ltd<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03364.x","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T19:33:13Z","timestamp":1087327993000},"page":"767-772","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy of transanal endoscopic microsurgery in the management of rectal polyps"],"prefix":"10.1111","volume":"19","author":[{"given":"CAMERON","family":"PLATELL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVA","family":"DENHOLM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREGORY","family":"MAKIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.5694\/j.1326-5377.2000.tb139295.x","article-title":"Flexible sigmoidoscopy screening for colorectal cancer in average\u2010risk people: update of a community\u2010based project","volume":"0","author":"Collett J","year":"2000","journal-title":"Med. 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