{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:04:20Z","timestamp":1760954660084},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T00:00:00Z","timestamp":1087257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> infection and non\u2010steroidal anti\u2010inflammatory drugs are two major causes of gastric injury but the effect of <jats:italic>H.\u2003pylori<\/jats:italic> eradication on the development of aspirin\u2010induced gastric mucosal injury is unclear. The aim of the present study was to investigate the effect of <jats:italic>Helicobacter pylori<\/jats:italic> eradication on gastroduodenal mucosal injury induced by antithrombotic doses of aspirin.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients who had been planned to start on medium\u2010dose aspirin (300\u2003mg) for any kind of indication were included in the study. All subjects underwent upper gastrointestinal endoscopy for determination of <jats:italic>H.\u2003pylori<\/jats:italic> status and Lanza score. The <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive patients were randomized to receive either aspirin\u2003+\u2003eradication (omeprazole 20\u2003mg b.i.d. and amoxicillin 500\u2003mg q.i.d. for 2\u2003weeks) or aspirin\u2003+\u2003placebo eradication. Endoscopic reassessment was done 4\u2003months after the onset of aspirin or when symptoms developed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Thirty\u2010two patients (placebo group <jats:italic>n<\/jats:italic>\u2003=\u200316, <jats:italic>H.\u2003pylori<\/jats:italic>\u2010eradicated group <jats:italic>n<\/jats:italic>\u2003=\u200316) completed the study and Lanza scores of both groups were similar before treatment. Lanza scores significantly increased in the placebo group (0.69\u2003\u00b1\u20030.87 vs 2.25\u2003\u00b1\u20031.3, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and did not change in the <jats:italic>H.\u2003pylori<\/jats:italic>\u2010eradicated group after aspirin treatment (0.43\u2003\u00b1\u20030.72 vs 0.75\u2003\u00b1\u20030.93, <jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> eradication may prevent medium\u2010dose aspirin\u2010induced gastroduodenal mucosal injury.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03374.x","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T19:33:13Z","timestamp":1087327993000},"page":"773-777","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of <i>Helicobacter pylori<\/i> eradication on anti\u2010thrombotic dose aspirin\u2010induced gastroduodenal mucosal injury"],"prefix":"10.1111","volume":"19","author":[{"given":"ADNAN","family":"GIRAL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OSMAN","family":"\u00d6ZDOGAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7IGDEM A","family":"\u00c7ELIKEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NURDAN","family":"T\u00d6Z\u00dcN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NEFISE B","family":"ULUSOY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CEM","family":"KALAYCI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1001\/jama.1980.03300330019023","article-title":"A randomized, controlled trial of aspirin in persons recovered from myocardial infarction","volume":"243","author":"Aspirin Myocardial Infarction Study Resarch Group.","year":"1980","journal-title":"JAMA"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511283132201"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.316"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907203210301"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110313251801"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92233-R"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92619-Q"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0016-5085(88)90349-6","article-title":"Relationship between Campylobacter pylori and gastritis in healty humans after administration of placebo or indomethacin","volume":"95","author":"Peterson WL","year":"1988","journal-title":"Gastroenterology"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103293441304"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90665-8"},{"key":"e_1_2_5_12_2","first-page":"1398","article-title":"Nonsteroidal anti\u2010inflammatory drug\u2010associated gastric ulcers do not require Helicobacter pylori for their development","volume":"87","author":"Laine L","year":"1992","journal-title":"Am. 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