{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:36:08Z","timestamp":1793975768915,"version":"4.8.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T00:00:00Z","timestamp":1084492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aims:\u2002<\/jats:bold> Often a cause for chronic non\u2010specific diarrhea (\u22653\u2003stools per day for more than 4\u2003weeks) is not identified. Small bowel bacterial overgrowth (SBO) can occur without morphological damage and remains difficult to diagnose. Often diarrhea is treated empirically with antibiotics with a good response. The aims of the present study were first to investigate the prevalence of SBO in a consecutive series of patients with chronic diarrhea and second to compare the utility of duodenal fluid culture and <jats:sup>14<\/jats:sup>C\u2010<jats:sc>d<\/jats:sc>\u2010xylose breath\/lactulose test in diagnosing SBO.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In the first study, the cause of chronic diarrhea was prospectively diagnosed in 87 subjects. In the second study, tests of SBO were compared in 18 subjects with chronic diarrhea and 15 subjects with reflux oesophagitis used as control subjects. Duodenal fluid was aspirated at endoscopy and cultured and later a <jats:sup>14<\/jats:sup>C\u2010<jats:sc>d<\/jats:sc>\u2010xylose breath\/lactulose test was performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In the first study, SBO was present in 48% of those with chronic diarrhea. In the second study, the diarrhea group had an average (range) stool frequency of 5.5 (3\u201310) per day and had normal duodenal biopsies. A total of 33%, 50%, 67% of subjects had SBO by duodenal culture alone, by a <jats:sup>14<\/jats:sup>C\u2010<jats:sc>d<\/jats:sc>\u2010xylose breath\/lactulose test alone and by a combination of both tests, respectively. In the control group, 0%, 13% and 13% had SBO by duodenal culture alone, by <jats:sup>14<\/jats:sup>C\u2010<jats:sc>d<\/jats:sc>\u2010xylose breath\/lactulose test alone and by combination of tests, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Small bowel bacterial overgrowth is a common (33\u201367%) cause of chronic diarrhea.<\/jats:p><jats:p>\u00a9 2004 Blackwell Publishing Asia Pty Ltd<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03376.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T07:32:29Z","timestamp":1104132749000},"page":"904-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Small bowel bacterial overgrowth is a common cause of chronic diarrhea"],"prefix":"10.1111","volume":"19","author":[{"given":"MARCUS","family":"TEO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN","family":"CHUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LAURI","family":"CHITTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CUONG","family":"TRAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STAMATIKI","family":"KRITAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSS","family":"BUTLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ADRIAN","family":"CUMMINS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70513-5"},{"key":"e_1_2_5_3_2","first-page":"202","volume-title":"Ecology of the Small Intestine","author":"Cummins AG.","year":"2000"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-999-0107-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90436-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6395.789"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01961.x"},{"key":"e_1_2_5_8_2","first-page":"149","article-title":"Small intestinal function in chronic relapsing pancreatitis","volume":"32","author":"Lembeke B","year":"1985","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065533"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018880524829"},{"key":"e_1_2_5_11_2","first-page":"97","article-title":"Blind loop syndrome and small bowel bacterial contamination","volume":"11","author":"Isaccs PET","year":"1983","journal-title":"Clin. 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