{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T23:49:54Z","timestamp":1717458594114},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T00:00:00Z","timestamp":1087257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Previous studies with cisapride reported conflicting results in patients with constipation\u2013predominant irritable bowel syndrome (IBS). To gain further evidence, this randomized double\u2010blind study was carried out.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Eighty\u2010two symptomatic outpatients were randomized to receive either 5\u2003mg oral cisapride or placebo three times daily for a period of 12 weeks. In patients without satisfactory improvement after 4 weeks, the dose was doubled. Symptom evaluation used visual analog scales (VAS) and the investigators\u2019 global assessment.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> After 4 weeks, in 18 (45%) cisapride and 24 (57%) placebo patients the dose was doubled because of insufficient improvement of symptoms. The mean VAS score for patients\u2019 global rating of IBS symptoms at baseline was 67.5\u2003mm for cisapride <jats:italic>versus<\/jats:italic> 70.7\u2003mm for placebo, and improved to 38.4\u2003mm <jats:italic>versus<\/jats:italic> 44.5\u2003mm after 12 weeks of treatment. Investigators rated the overall effect of therapy as good or excellent in 70% of the cisapride and 50% of the placebo group. Neither these nor further efficacy parameter differences reached statistical significance.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results indicate that the effect of 15\u201330\u2003mg cisapride daily on symptoms of constipation\u2010predominant IBS is not significantly superior to placebo. During the 12 week treatment of this trial cisapride proved to be safe and tolerable.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03384.x","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T19:33:13Z","timestamp":1087327993000},"page":"744-749","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cisapride treatment of constipation\u2013predominant irritable bowel syndrome is not superior to placebo"],"prefix":"10.1111","volume":"19","author":[{"given":"DIETER J","family":"ZIEGENHAGEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WOLFGANG","family":"KRUIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90275-P"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00262.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106143442407"},{"issue":"1","key":"e_1_2_6_5_2","first-page":"121","article-title":"Cisapride accelerates total intestinal transit in patients with irritable bowel syndrome associated constipation","volume":"43","author":"Passaretti S","year":"1987","journal-title":"Progr. 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