{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:49:43Z","timestamp":1760608183457},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T00:00:00Z","timestamp":1242864000000},"content-version":"vor","delay-in-days":1601,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Steering Committee for the Prevention and Control of Infectious Diseases in Asia recently conducted a survey of primary\u2010care physicians in Asia, which revealed that many physicians administer boosters in their clinical practice and that there is considerable variation and uncertainty among physicians regarding this practice. This paper serves as a response to physicians\u2019 uncertainties by reviewing the literature regarding the administration of hepatitis B vaccine boosters in high endemicity areas and presenting the Steering Committee's guidelines for booster administration. While there are few data to support a need for routine hepatitis B vaccine boosters as a public health measure, they help to provide reassurance of immunity against breakthrough infection in certain risk groups. In clinical practice, primary\u2010care physicians must exercise their judgment regarding the need for booster vaccination on an individual basis. This paper examines the available literature on the administration and value of hepatitis B vaccine boosters, explores the differences between the public health approach and clinical practice, and provides guidelines for those who use boosters in high endemicity Asian populations. Relevant articles were identified through searches of MEDLINE (1975\u20132003) and the Cochrane Library, using \u2018hepatitis B\u2019 and \u2018booster\u2019 as primary search terms. Guidelines for those who decide to administer hepatitis B vaccine boosters include: boosting approximately 10\u201315\u2003years after primary vaccination; boosting rather than not when monitoring of antibody levels is not feasible; boosting immunocompromised patients when the antibody to hepatitis B surface antigen titer falls below 10\u2003mIU\/mL; and boosting healthcare workers based on the endemicity of the particular country.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03398.x","type":"journal-article","created":{"date-parts":[[2004,12,6]],"date-time":"2004-12-06T12:10:22Z","timestamp":1102335022000},"page":"5-10","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Hepatitis B vaccine boosters: Is there a clinical need in high endemicity populations?"],"prefix":"10.1111","volume":"20","author":[{"given":"T JACOB","family":"JOHN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRAHAM","family":"COOKSLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,21]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290349"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(96)00062-X"},{"key":"e_1_2_9_4_2","unstructured":"YangTY HuangLM LeeCY ChiangBL HsuHM ChiWK.Humoral and cellular immunity after 15 years of hepatitis B vaccination. 166th Scientific Meeting of the Chinese Taipei Pediatric Association 7\u20138 April 2001 Taipei Taiwan ROC. 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