{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:32:49Z","timestamp":1773657169069,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T00:00:00Z","timestamp":1084406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> A 70\u2010kDa heat shock protein (stress\u2010inducible HSP70, HSP72) has been reported to be a cytoprotectant in a variety of organs. It has been reported that HSP72 protected non\u2010cirrhotic rats against endotoxemia. However, its cytoprotective effect against endotoxemia in cirrhotic rats has not yet been studied. In this study, we investigated the cytoprotective effect of HSP72 on lipopolysaccharide (LPS)\u2010induced liver injury in carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced cirrhotic rats.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Liver cirrhosis was produced by an 8\u2010week intraperitoneal injection of CCl<jats:sub>4<\/jats:sub> in male Sprague\u2013Dawley rats. Expression of HSP72 was investigated using western blot analysis. Cirrhotic rats were given an intraperitoneal injection of LPS (10\u2003mg\/kg) with or without hyperthermia (42.5\u00b0C, 15\u2003min) preconditioning. Liver injury was assessed biochemically (aspartate transaminase, alanine transaminase, bilirubin, lactate dehydrogenase, creatinine) and histologically. The plasma tumor necrosis factor (TNF)\u2010\u03b1 level was determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Hyperthermia preconditioning induced a 4\u2010fold increase in HSP72 in the cirrhotic rat liver. Pre\u2010induction of HSP72 prevented LPS\u2010induced liver injury, as evaluated using serum biochemical parameters and histology with reduced TNF\u2010\u03b1 response.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These findings suggest that pre\u2010induction of HSP72 may provide therapeutic strategies for Gram\u2010negative sepsis\u2010induced liver injury in liver cirrhosis.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03401.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T07:32:29Z","timestamp":1104132749000},"page":"884-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Induction of a 72\u2010kDa heat shock protein and protection against lipopolysaccharide\u2010induced liver injury in cirrhotic rats"],"prefix":"10.1111","volume":"19","author":[{"given":"KEN\u2010ICHIRO","family":"MIKAMI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHIRO","family":"OTAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKASHI","family":"GOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KOUICHI","family":"MIURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGETOSHI","family":"OHSHIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUO","family":"YONEYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIUN\u2010GUEY","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAISUKE","family":"WATANABE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAISUKE","family":"SEGAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EI","family":"KATAOKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASARU","family":"ODASHIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUMIO","family":"WATANABE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32333-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(87)80003-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080207"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80424-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00053.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300515"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/355033a0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90005-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80367-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5403"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8290"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018892000606"},{"key":"e_1_2_6_14_2","first-page":"R1447","article-title":"Hyperthermia protects mice against the lethal effects of endotoxin","volume":"265","author":"Hotchkiss R","year":"1993","journal-title":"Am. 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