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The clinical spectrum of this disease may range from a mild, non\u2010specific diarrhea to severe colitis with toxic megacolon, perforation, and death. PMC may affect all age groups, although a lower incidence has been noted in children. Ampicillin, amoxicillin, the second\u2010 and third\u2010generation cephalosporins and clindamycin are the drugs most frequently associated with development of PMC, although nearly all antimicrobials have been implicated as causes of diarrhea and colitis. Discontinuation of antibiotics and supportive therapy usually lead to resolution of this disorder. Administration of oral vancomycin or other therapeutic regimens may be needed.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03466.x","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T14:40:17Z","timestamp":1106923217000},"page":"182-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pseudomembranous colitis in children"],"prefix":"10.1111","volume":"20","author":[{"given":"ITZHAK","family":"BROOK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,28]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237064"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.3.678"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(99)90085-3"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2307\/30141083"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198912000-00010"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500010081036"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/324025"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/520276"},{"key":"e_1_2_9_10_2","first-page":"1312","article-title":"Pseudomembranous colitis: presence of clostridial toxin","volume":"2","author":"Larton HE","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401273300406"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91781-X"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.1952"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115957"},{"key":"e_1_2_9_15_2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/jcm.10.6.880-884.1979","article-title":"Cultures for Clostridium difficile in stools containing a cytotoxin neutralized by Clostridium sordellii antitoxin","volume":"10","author":"Willey S","year":"1979","journal-title":"J. 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