{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T22:10:06Z","timestamp":1734905406016,"version":"3.32.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>The therapeutic effect of combined administration of prokinetics and histamine H2 receptor antagonists (H2RA) in gastroesophageal reflux disease is reported to be superior to that of monotherapy with H2RA alone. In addition to its acid\u2010suppressing effect, the H2RA nizatidine also has a prokinetic action by suppressing acetylcholine esterase. The present multicenter, randomized controlled study was performed to investigate whether nizatidine is superior to famotidine, which does not suppress acetylcholine esterase activity, in maintenance therapy for erosive esophagitis. In addition, the question as to whether the grade of erosive esophagitis affects the non\u2010recurrence rate during the maintenance therapy with H2RA was also investigated.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>Seventy\u2010two patients with endoscopically healed erosive esophagitis after 8\u2003weeks of initial treatment with proton pump inhibitors were randomly divided into two groups. Patients in the nizatidine group were treated with 150\u2003mg nizatidine twice a day (b.i.d.), while patients in the famotidine group were treated with 20\u2003mg famotidine b.i.d. for 6\u2003months. At the end of therapy, and at the time when patients complained of symptoms, endoscopic investigations were repeated to find out whether the esophagitis had recurred.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Nizatidine produced a significantly higher non\u2010recurrence rate than famotidine (<jats:italic>P\u2003=<\/jats:italic>\u20030.049 in intention\u2010to\u2010treat [ITT] analysis). This difference of remission rate between nizatidine and famotidine was observed mainly in grade B esophagitis (<jats:italic>P\u2003=<\/jats:italic>\u20030.016 in ITT analysis).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>Nizatidine is a more effective H2RA than famotidine in the maintenance therapy of patients with reflux esophagitis.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03546.x","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T14:40:17Z","timestamp":1106923217000},"page":"281-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative study of nizatidine and famotidine for maintenance therapy of erosive esophagitis"],"prefix":"10.1111","volume":"20","author":[{"given":"NAOHARU","family":"HAMAMOTO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMOYUKI","family":"HASHIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KYOICHI","family":"ADACHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUYA","family":"HIRAKAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHUNJI","family":"ISHIHARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HARUE","family":"INOUE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROYUKI","family":"TANIURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASATOSHI","family":"NIIGAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHUICHI","family":"SATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHINORI","family":"KUSHIYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"SUETSUGU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TATSUYA","family":"MIYAKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHIKAZU","family":"KINOSHITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(81)80072-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899509031939"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510263331703"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02785.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.9.968"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.989_l.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90706-4"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(89)80012-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.11.767"},{"key":"e_1_2_6_11_2","first-page":"152","article-title":"Gastroprokinetic activity of nizatidine, a new H2\u2010receptor antagonist, and its possible mechanism of action in dogs and rats","volume":"264","author":"Ueki S","year":"1993","journal-title":"J. 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