{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:21:09Z","timestamp":1780489269537,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,19]],"date-time":"2005-01-19T00:00:00Z","timestamp":1106092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Melatonin is a hormone involved in the transduction of photoperiodic information, and appears to modulate a variety of neural and endocrine functions. The present study was designed to determine the impact of continuous darkness (CD) on acute gastric and colonic inflammation and the involvement of melatonin receptors in the darkness\u2010related alterations in oxidant gut injury.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Rats were housed either in CD or in standardized light\/dark (12\/12\u2003h) cycles for 15\u2003days before the induction of colitis or gastric ulcer. Luzindole (MT<jats:sub>2<\/jats:sub> receptor antagonist) was given at a dose of 0.25\u2003mg\/kg intraperitoneally 30\u2003min before and 6 and 18\u2003h following the induction of colitis with acetic acid or gastric ulcer with ethanol. Rats were decapitated at 24\u2003h, and the colons and stomachs were removed for macroscopic scoring, histologic assessment and for the determination of tissue malondialdehyde and glutathione levels.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All inflammation parameters were increased by acetic acid\u2010induced colitis or ethanol\u2010induced gastric ulcer compared with the control group. Our results indicate that the severity of both gastric and colonic injury is reduced by a 2\u2010week exposure to CD prior to the induction of inflammatory event, while luzindole treatment reversed the protective effect of CD on the colonic and gastric injury. However, darkness\u2010related alterations in malondialdehyde and glutathione levels were not altered by luzindole.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Although the CD\u2010induced amelioration of gut injury involves melatonin receptors, the direct antioxidant effects on melatonin appear to be independent of receptor activity.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2004.03579.x","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T14:40:17Z","timestamp":1106923217000},"page":"294-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: Both receptor and non\u2010receptor\u2010mediated processes"],"prefix":"10.1111","volume":"20","author":[{"given":"H\u00dcLYA","family":"\u00c7EV\u00cdK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00d6ZDE","family":"ERKANLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FER\u00cdHA","family":"ERCAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7A\u011ela A","family":"\u00cd\u015eMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BERRAK \u00c7","family":"YE\u011eEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(91)90087-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(94)00786-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/074873048600100106"},{"key":"e_1_2_6_5_2","first-page":"287","volume-title":"Frontiers in Neuroendocrinology.","author":"Reiter RJ","year":"1982"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1996.tb00249.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(03)00021-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.1999.0810"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2003_3637"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(98)00107-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.10.3.467"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(99)00160-5"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2001.300101.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1995.tb00168.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.16.s2.11.x"},{"key":"e_1_2_6_16_2","first-page":"21","article-title":"Ulcer protective effect of melatonin during artificial simulation of desynchronization in rats","volume":"8","author":"Komarov FI","year":"2000","journal-title":"Vestn. 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