{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:43:57Z","timestamp":1792604637550,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,3,15]],"date-time":"2005-03-15T00:00:00Z","timestamp":1110844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> The influence of <jats:italic>Helicobacter pylori<\/jats:italic> on gastric acid secretion differs with the status of gastritis. The histological characteristics of gastritis in <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive patients with reflux esophagitis have not been fully investigated. We therefore studied the pattern of endoscopic gastric mucosal atrophy and degree of histological gastritis in such patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Subjects comprised 41 <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive patients with reflux esophagitis, 41 age\u2010 and sex\u2010matched patients with duodenal ulcer, and 41 patients with early gastric cancer. The endoscopic pattern of gastric mucosal atrophy was reviewed, and the degree of histological gastritis in biopsy specimens from the antrum and corpus was assessed in accordance with the updated Sydney system.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The grade of endoscopic and histological gastric mucosal atrophy in patients with reflux esophagitis was significantly lower than that in patients with gastric cancer, and the histological scores for antral atrophy and metaplasia in patients with reflux esophagitis tended to be lower than those in patients with duodenal ulcer. In patients with reflux esophagitis and duodenal ulcer, the scores for antral inflammation and activity tended to be higher than those for the corpus. Conversely, the inflammation and activity score in patients with early gastric cancer showed a corpus\u2010predominant gastritis pattern.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive patients with reflux esophagitis, the degree of endoscopic gastric mucosal atrophy is low and histologically there is an antral\u2010predominant gastritis pattern. Therefore, gastric acid secretion in <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive patients with reflux esophagitis may be augmented by <jats:italic>H.\u2003pylori<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2005.03779.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T12:42:01Z","timestamp":1281962521000},"page":"682-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of gastritis in patients with <i>Helicobacter pylori<\/i>\u2010positive reflux 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