{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:26:24Z","timestamp":1754486784201},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,7]],"date-time":"2005-11-07T00:00:00Z","timestamp":1131321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Differentiation between functional dyspepsia and early chronic pancreatitis is difficult because these diseases do not produce specific abnormalities in laboratory testing. The aim of this study was to examine the potential efficacy of camostat mesilate, a protease inhibitor, against functional dyspepsia and to characterize patients with favorable responses.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Dyspeptic patients who exhibited no abnormalities on laboratory blood and urine testing, abdominal ultrasonography and upper gastrointestinal endoscopy were randomized to receive camostat mesilate 200\u2003mg three times daily or famotidine 20\u2003mg twice daily for 4\u2003weeks. Symptoms severity was recorded before and at 2 and 4\u2003weeks after starting treatment using a visual analog scale.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Epigastralgia was significantly improved after 2 and 4\u2003weeks of treatment in both groups (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.01); this improvement tended to be more marked in the camostat mesilate group (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05 at 2\u2003weeks). The beneficial effect of camostat mesilate on epigastralgia was more prominent in chronic alcohol drinkers at 2\u2003weeks (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05) and 4\u2003weeks (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.01).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Camostat mesilate is superior to famotidine for relieving epigastralgia in patients with functional dyspepsia. Its pain\u2010relieving effect is greater in patients who habitually drink alcohol.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2005.04041.x","type":"journal-article","created":{"date-parts":[[2005,11,7]],"date-time":"2005-11-07T13:40:01Z","timestamp":1131370801000},"page":"767-771","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: Is camostat mesilate effective?"],"prefix":"10.1111","volume":"21","author":[{"given":"NOBUO","family":"ASHIZAWA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMOYUKI","family":"HASHIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TATSUYA","family":"MIYAKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHIHIRO","family":"SHIZUKU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMONORI","family":"IMAOKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHIKAZU","family":"KINOSHITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"844","article-title":"Efficacy of FOY\u2010305 in the treatment of chronic pancreatitis: a multi\u2010center, randomized, controlled, double\u2010blind, comparative study","volume":"16","author":"Ishii K","year":"1984","journal-title":"Gendai Iryou"},{"issue":"1","key":"e_1_2_5_3_2","first-page":"145","article-title":"Clinical effects of camostat in chronic pancreatitis","volume":"10","author":"Kanoh M","year":"1989","journal-title":"Biomed Res."},{"key":"e_1_2_5_4_2","first-page":"4151","article-title":"Efficacy of camostat mesilate on chronic pancreatitis and its effectiveness on long\u2010term therapy for prevention of recurrence of pancreatitis","volume":"15","author":"Mizukami Y","year":"1994","journal-title":"Ther. 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