{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:41:00Z","timestamp":1761154860816},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T00:00:00Z","timestamp":1139961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Hepatic ischemia\u2013reperfusion injury may lead to remote organ failure with mortal respiratory dysfunction. The aim of the present study was to analyze the possible protective effects of methimazole on lungs after hepatic ischemia\u2013reperfusion injury.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Forty male Wistar albino rats were randomized into five groups: a control group, in which bilateral pulmonary lobectomy was done; a hepatic ischemia\u2013reperfusion group, in which bilateral pulmonary lobectomy was done after hepatic ischemia\u2013reperfusion; a thyroidectomy\u2013ischemia\u2013reperfusion group (total thyroidectomy followed by, 7\u2003days later, bilateral pulmonary lobectomy after hepatic ischemia\u2013reperfusion); a methimazole\u2013ischemia\u2013reperfusion group (following methimazole administration for 7\u2003days, bilateral pulmonary lobectomy was done after hepatic ischemia\u2013reperfusion); and a methimazole\u2003+<jats:sc>l<\/jats:sc>\u2010thyroxine\u2013ischemia\u2013reperfusion group (following methimazole and <jats:sc>l<\/jats:sc>\u2010thyroxine administration for 7\u2003days, bilateral pulmonary lobectomy was performed after hepatic ischemia\u2013reperfusion). Pulmonary tissue specimens were evaluated histopathologically and for myeloperoxidase and malondialdehyde levels.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All of the ischemia\u2013reperfusion intervention groups had higher pulmonary injury scoring indices than the control group (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001). Pulmonary injury index of the ischemia\u2013reperfusion group was higher than that of both the methimazole\u2010supplemented hypothyroid and euthyroid groups (<jats:italic>P\u2003<\/jats:italic>=\u20030028; <jats:italic>P<\/jats:italic>\u2003=\u20030,038, respectively) and was similar to that of the thyroidectomized group. Pulmonary tissue myeloperoxidase and malondialdehyde levels in the ischemia\u2013reperfusion group were similar with that in the thyroidectomized rats but were significantly higher than that in the control, and both the methimazole\u2010supplemented hypothyroid and euthyroid groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Methimazole exerts a protective role on lungs during hepatic ischemia\u2013reperfusion injury, which can be attributed to its anti\u2010inflammatory and anti\u2010oxidant effects rather than hypothyroidism alone.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04202.x","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T15:59:51Z","timestamp":1140019191000},"page":"704-709","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Methimazole protects lungs during hepatic ischemia\u2013reperfusion injury in rats: An effect not induced by hypothyroidism"],"prefix":"10.1111","volume":"22","author":[{"given":"Tanju","family":"T\u00fct\u00fcnc\u00fc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7agatay","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"G\u00f6zalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunus Nadi","family":"Y\u00fcksek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Bilgihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuri Aydin","family":"Kama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5311"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90460-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199910000-00013"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1997.4998"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005950170198"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199002000-00008"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199601000-00008"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300622"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.4.1062"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199312000-00011"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199806000-00009"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.1999.tb00037.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00147-1"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240221"},{"key":"e_1_2_5_16_2","first-page":"21","article-title":"Antithyroid drug\u2010induced immunomodulation in Graves' disease patients","volume":"56","author":"Lechpammer M","year":"2002","journal-title":"Acta Med. 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