{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:02:48Z","timestamp":1791514968267,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The purpose of the present paper was to evaluate the efficacy and tolerability of amoxicillin\u2013clavulanate and tetracycline\u2010based quadruple therapy as an alternative second\u2010line treatment for <jats:italic>H.\u2003pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The study subjects consisted of 54 patients infected with <jats:italic>H.\u2003pylori,<\/jats:italic> in whom initial triple therapy had failed. Subjects were randomized to receive the following 7\u2010day therapies: (i) pantoprazole 40\u2003mg b.i.d., tripotassium dicitrate bismuthate 300\u2003mg q.i.d., amoxicillin\u2013clavulanate 1000\u2003mg b.i.d., and tetracycline 500\u2003mg q.i.d. (PBAT); or (ii) pantoprazole 40\u2003mg b.i.d., tripotassium dicitrate bismuthate 300\u2003mg q.i.d., metronidazole 500\u2003mg t.i.d., and tetracycline 500\u2003mg q.i.d. (PBMT). Eradication rates based on antibiotic susceptibility, drug compliance and side\u2010effect rates were evaluated and compared.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The <jats:italic>H.\u2003pylori<\/jats:italic> eradication rates were 16.0%\/17.4% with PBAT and 65.5%\/70.4% with PBMT by intention\u2010to\u2010treat (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and per\u2010protocol analyses (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), respectively. In patients who received PBAT, the eradication rates were only 16.7% (2\/12) for both amoxicillin and tetracycline\u2010susceptible <jats:italic>H.\u2003pylori<\/jats:italic> strains. Drug compliance and side\u2010effect rates were similar in the two groups.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Despite high individual <jats:italic>in vitro<\/jats:italic> antimicrobial activity, amoxicillin\u2013clavulanate and tetracycline\u2010based quadruple therapy showed low eradication rates, which strongly suggests that it should not be considered as a therapeutic option for <jats:italic>H.\u2003pylori<\/jats:italic> eradication.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04291.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T01:27:58Z","timestamp":1145582878000},"page":"1590-1595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combinations containing amoxicillin\u2013clavulanate and tetracycline are inappropriate for <i>Helicobacter pylori<\/i> eradication despite high <i>in vitro<\/i> susceptibility"],"prefix":"10.1111","volume":"21","author":[{"given":"Jae Hee","family":"Cheon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Mogg","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Chae","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Sung","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01169.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00537.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.i40"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00542.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050668"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200211000-00012"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37051"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1997.00551.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.4.459"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4843-4847.2004"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4856-4858.2004"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4832-4834.2004"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf041"},{"key":"e_1_2_7_16_2","first-page":"111","article-title":"Trial of moxifloxacin\u2010containing triple therapy after initial and second\u2010line treatment failures for Helicobacter pylori infection","volume":"45","author":"Cheon JH","year":"2005","journal-title":"Korean J. 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