{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:19:53Z","timestamp":1790543993159,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Exclusive enteral feeding has been shown to be as efficacious as corticosteroids in inducing remission in children with Crohn\u2019s disease (CD), with additional nutritional benefits. The use of polymeric formulae provides superior palatability and acceptance over elemental feeds, but polymeric formulae have not been universally adopted. The present retrospective analysis of enteral feeding in children with Crohn\u2019s disease aims to demonstrate the short\u2010term benefits of enteral feeding in children upon disease activity and nutrition parameters.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The case records of children with CD managed with exclusive enteral nutrition (EEN) by a multidisciplinary team over a 2\u2010year period were reviewed. Data relating to therapy, background disease details, and outcome were collated. Primary outcome measures established were weight change and disease activity (Pediatric Crohn\u2019s Disease Activity Index: PCDAI).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Twenty\u2010seven children received EEN with polymeric formulae. Fifteen children had newly diagnosed CD and 12 had known long\u2010standing CD. Twenty\u2010four children completed the prescribed period of EEN. Twelve of 15 (80%) newly diagnosed CD and seven of 12 (58%) with long\u2010standing disease entered remission. Children with newly diagnosed CD responding to EEN took all feeds orally and gained an average of 4.7\u2003\u00b1\u20033.5\u2003kg with mean PCDAI decreasing from 37.1\u2003\u00b1\u200310.8 to 6.7\u2003\u00b1\u20035.1 after 8\u2003weeks. In addition, four children continued supplementary polymeric formula (without other medical therapies) and all have maintained remission during an average follow\u2010up period of 15.2\u2003months.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Exclusive enteral feeds induced remission in 80% of children with newly diagnosed CD (on intention\u2010to\u2010treat basis) when used as sole initial therapy while also improving nutritional status. All newly diagnosed children treated with EEN, who were able to establish feeds, achieved remission. In addition, remission may be prolonged with oral supplementary formula as sole ongoing treatment. Further study of the role(s) of enteral feeds and of longer\u2010term benefits of enteral feeding in children with CD is now required.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04294.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T01:27:58Z","timestamp":1145582878000},"page":"1609-1614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Exclusive enteral feeding as primary therapy for Crohn\u2019s disease in Australian children and adolescents: A feasible and effective approach"],"prefix":"10.1111","volume":"21","author":[{"given":"Andrew S","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie E","family":"Whitten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Lemberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Clarkson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Vitug\u2010Sales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D","family":"Bohane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"613","volume-title":"Pediatric Gastrointestinal Disease.","author":"Griffiths AM","year":"2000"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01482.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200103000-00012"},{"key":"e_1_2_5_5_2","first-page":"250","article-title":"Elemental diet versus prednisone as initial therapy in Crohn\u2019s disease: early and long\u2010term results","volume":"100","author":"Seidman EG","year":"1991","journal-title":"Gastroenterology"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.6.778"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/00365521.1990.12067097","article-title":"Feasibility and effectiveness of a defined\u2010formula diet regimen in treating active Crohn\u2019s disease. 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