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In this study, the effects of zinc L\u2010carnosine, an anti\u2010ulcer drug, were evaluated on expression of heat shock protein (hsp) 72 and cytoprotection in gastric mucosa in a rat model of PHG.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Portal hypertensive gastropathy with liver cirrhosis was induced by bile duct ligation for 4\u2003weeks in male Sprague\u2013Dawley rats. Expression of gastric mucosal hsp72 was evaluated by Western blotting at 6\u2003h after intragastric administration of L\u2010carnosine, zinc sulfate, or zinc L\u2010carnosine. Blood was also collected for determination of serum zinc level. Mucosal protective abilities against hydrochloric acid (HCl) (0.6N) followed by pretreatment with L\u2010carnosine, zinc sulfate or zinc L\u2010carnosine were also studied.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> L\u2010carnosine, zinc sulfate, and zinc L\u2010carnosine induced hsp72 in gastric mucosa of rats with bile duct ligation. Zinc sulfate and zinc L\u2010carnosine suppressed HCl\u2010induced mucosal injury. However, L\u2010carnosine could not suppress HCl\u2010induced mucosal injury. Serum zinc levels were significantly elevated after zinc L\u2010carnosine administration. Furthermore, pretreatment with zinc L\u2010carnosine (30\u2013300\u2003mg\/kg) increased the expression of hsp72 in gastric mucosa and prevented HCl\u2010induced mucosal injury in rats with bile duct ligation in a dose\u2010dependent manner.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Zinc derivatives, especially zinc L\u2010carnosine, protected portal hypertensive gastric mucosa with increased hsp72 expression in cirrhotic rats. It is postulated that zinc L\u2010carnosine may be beneficial to the mucosal protection in PHG as a \u2018chaperon inducer\u2019.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04328.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T01:27:58Z","timestamp":1145582878000},"page":"1669-1674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Zinc L\u2010carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72"],"prefix":"10.1111","volume":"21","author":[{"given":"Ken\u2010Ichiro","family":"Mikami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiro","family":"Otaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Endoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetoshi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Segawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ei","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryutaro","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Odashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8555"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90458-D"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536055"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90218-X"},{"key":"e_1_2_6_6_2","first-page":"167","article-title":"Results of surgical management of hemorrhagic gastritis in patients with gastroesophageal varices","volume":"155","author":"Sarfeh IJ","year":"1982","journal-title":"Surg. 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