{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:18:41Z","timestamp":1760188721827},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T00:00:00Z","timestamp":1145577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> is a major cause of chronic gastritis and peptic ulcer disease and a definite carcinogen for gastric adenocarcinoma. However, the underlying pathogenic mechanisms are not fully understood. Interleukin\u20101 (IL\u20101) is a key cytokine involved in <jats:italic>H.\u2003pylori<\/jats:italic>\u2010induced gastric inflammation. The present study aimed to determine polymorphisms of <jats:italic>IL\u20101B<\/jats:italic> and <jats:italic>IL\u20101 receptor antagonist<\/jats:italic> (<jats:italic>IL\u20101RN<\/jats:italic>) genes and their association with <jats:italic>H.\u2003pylori<\/jats:italic> infection and gastroduodenal diseases in Chinese patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Three hundred and ninety\u2010nine patients with gastroduodenal diseases (129 chronic gastritis, 127 duodenal ulcer and 143 non\u2010cardiac gastric cancer) and 264 healthy controls were genotyped for <jats:italic>IL\u20101B\u2010<\/jats:italic>511 and <jats:italic>IL\u20101RN<\/jats:italic> gene polymorphisms by the PCR\u2010RFLP method. <jats:italic>H.\u2003pylori<\/jats:italic> infection status was determined by a validated serological test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The frequency of <jats:italic>IL\u20101B\u2010<\/jats:italic>511 T allele was significantly higher in <jats:italic>H.\u2003pylori<\/jats:italic> positive patients with non\u2010cardiac gastric cancer than in both <jats:italic>H.\u2003pylori<\/jats:italic> negative patients with non\u2010cardiac gastric cancer (60%<jats:italic>vs<\/jats:italic> 46%, <jats:italic>P<\/jats:italic>\u2003=\u20030.0342, OR\u2003=\u20031.666, 95% confidence interval [CI]: 1.045\u20132.656) and in healthy controls (60%<jats:italic>vs<\/jats:italic> 48%, <jats:italic>P<\/jats:italic>\u2003=\u20030.0071, OR\u2003=\u20031.665, 95%CI: 1.149\u20132.412). However, the polymorphism was not associated with chronic gastritis and duodenal ulcer. Multivariate logistic regression analyses identified that <jats:italic>IL\u20101B\u2010<\/jats:italic>511\u2003T\/T carrier status was an independent risk factor for non\u2010cardiac gastric cancer in the presence of <jats:italic>H.\u2003pylori<\/jats:italic> infection (adjusted OR\u2003=\u20033.01, 95%CI: 1.27\u20137.11, <jats:italic>P<\/jats:italic>\u2003=\u20030.01), and the frequency of <jats:italic>IL\u20101B\u2010<\/jats:italic>511 T allele was an increased risk factor for developing gastric cancer (<jats:italic>P<\/jats:italic>\u2003= 0.03, adjusted OR\u2003=\u20032.29, 95%CI: 1.08\u20134.86). There was no association between <jats:italic>IL\u20101RN<\/jats:italic> gene polymorphisms and <jats:italic>H.\u2003pylori<\/jats:italic> infection and other gastroduodenal diseases.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:italic>IL\u20101B\u2010<\/jats:italic>511 T allele is associated with <jats:italic>H.\u2003pylori<\/jats:italic> infection in non\u2010cardiac gastric cancer in a Chinese population. The <jats:italic>IL\u20101B\u2010<\/jats:italic>511 gene polymorphism appears to play an important role in gastric carcinogenesis in Chinese patients with <jats:italic>H.\u2003pylori<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04379.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T20:42:53Z","timestamp":1145652173000},"page":"234-239","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Association between <i>interleukin<\/i>\u20101 gene polymorphisms and <i>Helicobacter pylori<\/i> infection in gastric carcinogenesis in a Chinese population"],"prefix":"10.1111","volume":"22","author":[{"given":"Chun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry Hua\u2010Xiang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengguo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00227.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00169.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11680"},{"key":"e_1_2_6_5_2","first-page":"177","article-title":"Schistosomes, liver flukes and Helicobacter pylori","volume":"61","author":"International Agency for Research on Cancer.","year":"1994","journal-title":"IARC Monogr. 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