{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T16:32:17Z","timestamp":1697387537134},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T00:00:00Z","timestamp":1150156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Polymorphisms of GABA<jats:sub>A<\/jats:sub>\u03b16 (<jats:italic>GABRA6<\/jats:italic>)\u20101521 and <jats:italic>IL\u20101\u03b2<\/jats:italic>\u2010511 have been linked with susceptibility to stress and gastric acid secretion. The aim of this study was to assess psychiatric profiles and <jats:italic>GABRA6<\/jats:italic> and <jats:italic>IL\u20101\u03b2<\/jats:italic> genotypes in functional heartburn, an important esophageal reflux condition.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Psychological symptoms were assessed with a Brief Symptom Rating Scale and personality traits with a short\u2010form Maudsley Personality Inventory. DNA from 452 healthy controls, 80 controls with neurosis, and 122 patients with functional heartburn was genotyped with PCR\u2010RFLP technique.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Symptom\u2010scale parameters (except hostility) were significantly higher in patients with functional heartburn than in healthy controls; their neuroticism scores were also higher, but extroversion scores were lower. Distribution of <jats:italic>GABRA6<\/jats:italic> genotypes in patients with functional heartburn showed more heterozygotes than among healthy controls and neurotic subjects, but distributions of <jats:italic>IL\u20101\u03b2<\/jats:italic> genotypes were similar. Multiple logistic regression analysis showed <jats:italic>GABRA6<\/jats:italic> heterozygosity was significantly associated with functional heartburn (odds ratio, 2.37; 95% confidence interval, 1.36\u20134.12; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) even after adjustment for age, sex, <jats:italic>Helicobacter pylori<\/jats:italic> infection, General Symptom Index, and score of neuroticism.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Chinese patients with certain psychiatric characteristics and <jats:italic>GABRA6<\/jats:italic> heterozygosity are probably predisposed to functional heartburn, providing insight into this condition\u2019s psychopathology and genetics.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04441.x","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T12:07:22Z","timestamp":1150200442000},"page":"227-233","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>GABRA6<\/i> genetic polymorphism is associated with the risk of functional heartburn in Chinese"],"prefix":"10.1111","volume":"22","author":[{"given":"Yi\u2010Chia","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Mo","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Pei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Cheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Fong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaw\u2010Town","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Shiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03419.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200405000-00010"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.885"},{"key":"e_1_2_6_5_2","first-page":"1797","article-title":"Psychological distress in patients with gastroesophageal reflux disease","volume":"90","author":"Baker LH","year":"1995","journal-title":"Am. 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