{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:59Z","timestamp":1790172179859,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T00:00:00Z","timestamp":1148428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> In Western countries, polymorphism of pro\u2010inflammatory cytokine genes is associated with the development of gastric cancer and duodenal ulcer. The aim of this study was to clarify the association of polymorphisms of interleukin (<jats:italic>IL<\/jats:italic>)<jats:italic>\u20101\u03b2<\/jats:italic> and tumor necrosis factor (<jats:italic>TNF<\/jats:italic>)<jats:italic>\u2010\u03b1<\/jats:italic> with susceptibility to peptic ulcer diseases and gastric cancer in Japan.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The <jats:italic>IL\u20101\u03b2<\/jats:italic>\u2010511\/\u201031 and <jats:italic>TNF\u2010\u03b1<\/jats:italic>\u2010308\/\u2010857\/\u2010863\/\u20101031 genotypes were determined in <jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive patients with gastritis only (<jats:italic>n<\/jats:italic>\u2003=\u2003164), gastric ulcers (<jats:italic>n<\/jats:italic>\u2003=\u2003110), duodenal ulcers (<jats:italic>n<\/jats:italic>\u2003=\u200394), or gastric cancers (<jats:italic>n<\/jats:italic>\u2003=\u2003105), and in <jats:italic>H.\u2003pylori<\/jats:italic>\u2010negative controls (<jats:italic>n<\/jats:italic>\u2003=\u2003172).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Carriage of the alleles <jats:italic>TNF\u2010\u03b1\u2010<\/jats:italic>857\u2003T (odd ratio [OR], 1.826; 95% confidence interval [CI], 1.097\u20133.039), <jats:italic>TNF\u2010\u03b1\u2010<\/jats:italic>863 A (OR, 1.788; 95% CI, 1.079\u20132.905) and <jats:italic>TNF\u2010\u03b1<\/jats:italic>\u20101031\u2003C (OR, 1.912; 95% CI, 1.152\u20133.171) was associated with increased risk for gastric ulcer development. Carriage of the alleles <jats:italic>TNF\u2010\u03b1\u2010<\/jats:italic>857\u2003T (OR, 1.686; 95% CI, 1.003\u20132.832), <jats:italic>TNF\u2010\u03b1\u2010<\/jats:italic>863 A (OR, 1.863; 95% CI, 1.118\u20133.107) and <jats:italic>TNF\u2010\u03b1<\/jats:italic>\u20101031\u2003C (OR 2.074; 95% CI, 1.244\u20133.457) was also associated with increased risk of gastric cancer development. There was no relationship between the development of <jats:italic>H.\u2003pylori<\/jats:italic>\u2010related diseases and polymorphisms of <jats:italic>IL\u20101\u03b2<\/jats:italic>\u2010511\/\u201031 and <jats:italic>TNF\u2010\u03b1<\/jats:italic>\u2010308. The simultaneous carriage of three different high\u2010producer alleles of <jats:italic>TNF\u2010\u03b1<\/jats:italic>\u2010857\/\u2010863\/\u20101031 significantly increased the risk of gastric ulcer (OR, 6.57; 95% CI, 2.34\u201318.40) and gastric cancer (OR, 5.20; 95% CI, 1.83\u201314.78).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Polymorphisms in <jats:italic>TNF\u2010\u03b1<\/jats:italic> rather than <jats:italic>IL\u20101\u03b2<\/jats:italic> are associated with increased risk for gastric ulcers and gastric cancer in Japan. The simultaneous carriage of more than one high\u2010producer allele of <jats:italic>TNF\u2010\u03b1<\/jats:italic> further increased the risks for gastric ulcer and cancer.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04442.x","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T13:13:26Z","timestamp":1148476406000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Different effects of polymorphisms of tumor necrosis factor\u2010alpha and interleukin\u20101 beta on development of peptic ulcer and gastric cancer"],"prefix":"10.1111","volume":"22","author":[{"given":"Mitsushige","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Kajimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92613-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01501-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-12-199812150-00006"},{"issue":"11","key":"e_1_2_6_7_2","first-page":"10","article-title":"Relation between interleukin\u20101beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori","volume":"34","author":"Wang M","year":"1999","journal-title":"J. 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