{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:44:01Z","timestamp":1790297041678,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Gastric carcinoma (GC) with microsatellite instability (MSI) exhibits clinicopathological characteristics distinct from microsatellite\u2010stable (MSS) GC. Both MSI and MSS carcinomas are mostly associated with chronic gastritis infected by <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>Hp<\/jats:italic>). The relationship between <jats:italic>Hp<\/jats:italic>\u2010induced inflammation and the mutator pathway of MSI remains unclear. Recently, cytokine polymorphisms have been reported to affect the development of non\u2010cardia GC. The objective of this study was to elucidate the relationship between cytokine polymorphisms and MSI phenotypes.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In a case\u2010control study including 482 controls and 181 patients with GC, <jats:italic>interleukin<\/jats:italic> (<jats:italic>IL<\/jats:italic>)<jats:italic>\u20108 \u2013<\/jats:italic>251, <jats:italic>IL\u20101B<\/jats:italic>\u2212511, <jats:italic>IL\u20101RN<\/jats:italic>, and <jats:italic>tumor necrosis factor\u2010A<\/jats:italic> (<jats:italic>TNFA<\/jats:italic>) \u2212857 polymorphisms were genotyped. The presence of MSI and mutations in exons 5 to 8 of the <jats:italic>p53<\/jats:italic> gene were examined in GC cases. All clinicopathological data were collected from individual records.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> High and low frequency of MSI (MSI\u2010H and MSI\u2010L) and MSS were detected in 16 (8.8%), 14 (7.7%) and 151 (83.4%) GC cases, respectively. We found that <jats:italic>IL\u20108 \u2013<\/jats:italic>251 T\/T genotype was significantly associated with increased risk of MSI\u2010H GC compared to MSI\u2010L\/MSS GC and controls. We found no association between other cytokine polymorphisms and MSI\u2010H GC. The percentage of smokers and the frequency of <jats:italic>p53<\/jats:italic> mutations were significantly lower in MSI\u2010H than MSI\u2010L\/MSS GC. We found significant associations of MSI\u2010H with synchronous or metachronous multiple occurrence, antral location and intestinal type.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our study shows that MSI\u2010H GC is associated with <jats:italic>IL\u20108\u2013<\/jats:italic>251 T\/T (low expression genotype) and is inversely correlated with cigarette smoking.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04443.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T16:14:57Z","timestamp":1145981697000},"page":"1129-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["<i>Interleukin\u20108<\/i> gene polymorphism associated with susceptibility to non\u2010cardia gastric carcinoma with microsatellite 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