{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:06:00Z","timestamp":1793156760675,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T00:00:00Z","timestamp":1152057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Although mucosal protective agents have been used frequently for treatment of symptomatic gastritis, there has been no well\u2010controlled study of functional dyspepsia. The aim of this study was to assess the efficacy of a 4\u2010week treatment with rebamipide for the relief of overall dyspeptic symptoms and the improvement in quality of life from an untreated baseline in Japanese patients with functional dyspepsia.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In a double\u2010blinded, randomized, placebo\u2010controlled, single\u2010center study, 81 patients with functional dyspepsia were recruited and treated with rebamipide (100\u2003mg, t.i.d.) or placebo for 4\u2003weeks. Symptoms were assessed at baseline and at the end of the study period by a symptom questionnaire. Quality of life was evaluated by the QPD\u200332.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Data was analyzed for symptoms from 38 patients who received rebamipide and 33 patients who received placebo treatment. Overall symptoms were significantly improved in both the rebamipide and placebo treatment groups from the untreated baseline after 4\u2003weeks of treatment, and the mean changes in overall symptoms were not significantly different between the groups. However, the improvement in symptom score was significantly greater in the treatment arm than in the placebo arm for three items, which were bloating, belching, and pain or discomfort that was relieved after a meal. Regarding quality of life, social restriction and pain intensity were significantly improved in the rebamipide treatment group in per\u2010protocol analysis (<jats:italic>P\u2003<\/jats:italic>=\u20030.048 and <jats:italic>P<\/jats:italic>\u2003=\u20030.031, respectively).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Although rebamipide was not significantly better than placebo in reducing overall symptoms by 4\u2003weeks\u2019 treatment, it may partially improve the symptoms. It may also be beneficial in improvement of quality of life in Japanese patients with functional dyspepsia.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04446.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T05:52:21Z","timestamp":1152251541000},"page":"1826-1831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effect of a gastro\u2010protective agent, rebamipide, on symptom improvement in patients with functional dyspepsia: A double\u2010blind placebo\u2010controlled study in Japan"],"prefix":"10.1111","volume":"21","author":[{"given":"Hiroto","family":"Miwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Osada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Ohkusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811053391907"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018855724017"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02606.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000201312"},{"key":"e_1_2_5_6_2","first-page":"447","article-title":"Induction of cyclooxygenase\u20102 in rat gastric mucosa by rebamipide, a mucoprotective agent","volume":"295","author":"Sun WH","year":"2000","journal-title":"J. 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