{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:38:12Z","timestamp":1773923892731,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T00:00:00Z","timestamp":1150156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Evidence remains inconclusive as to whether eradication of <jats:italic>Helicobacter pylori<\/jats:italic> prevents ulcer relapse after simple closure of a perforated duodenal ulcer. This study was conducted to determine the effect of <jats:italic>H.\u2003pylori<\/jats:italic> eradication using a quadruple drug regimen along with a probiotic on ulcer recurrence after perforation closure.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 93 patients who had presented with perforated duodenal ulcer and had a simple closure of a duodenal perforation comprised the study group. Three months postoperatively, patients who were found to be positive for <jats:italic>H.\u2003pylori<\/jats:italic> infection (<jats:italic>n<\/jats:italic>\u2003=\u200360) were administered quadruple therapy consisting of omeprazole, clarithromycin, amoxicillin and colloidal bismuth subcitrate for 10\u2003days along with the probiotic <jats:italic>Lactobacillus sporogenes<\/jats:italic> for 14\u2003days. Diagnosis of <jats:italic>H.\u2003pylori<\/jats:italic> was carried out by urease test and histology. Patients were followed for 18\u2003months. Recurrence of ulcer was analyzed for correlation with <jats:italic>H.\u2003pylori<\/jats:italic> status.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of 60 patients who received <jats:italic>H.\u2003pylori<\/jats:italic> eradication therapy, 53 were available for subsequent follow up. <jats:italic>H.\u2003pylori<\/jats:italic> eradication was achieved in 43\/53 (81.1%) patients. The ulcer recurrence in the eradicated group was 18.6% (8\/43) compared to 70% (7\/10) in the noneradicated group (<jats:italic>P<\/jats:italic>\u2003= 0.003).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Eradication of <jats:italic>H.\u2003pylori<\/jats:italic> significantly reduces the relapse of duodenal ulcer after simple closure of perforation. Anti <jats:italic>H.\u2003pylori<\/jats:italic> therapy must be recommended for all <jats:italic>H.\u2003pylori<\/jats:italic> positive patients after simple closure of a perforated duodenal ulcer.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04490.x","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T12:07:22Z","timestamp":1150200442000},"page":"345-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>Helicobacter pylori<\/i> eradication prevents recurrence after simple closure of perforated duodenal ulcer"],"prefix":"10.1111","volume":"22","author":[{"given":"Ashitha C","family":"Bose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Kate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilakantan","family":"Ananthakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash Chandra","family":"Parija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"19","article-title":"Helicobacter pylori infection in patients with perforated duodenal ulcer","volume":"19","author":"Chowdhary SK","year":"1998","journal-title":"Trop. 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