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The aim of this study was to perform a meta\u2010analysis of the effects of prokinetic agents in patients with FD.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Prokinetic agents, including metoclopramide, domperidone, trimebutine, cisapride, itopride and mosapride, used for treatment of FD between 1951 and 2005 were identified. Twenty\u2010seven studies were selected. Difference in the probability of response between the interventional drug and placebo was used as a summary statistic for the treatment effect. Meta\u2010regression analysis was used to detect sources of heterogeneity.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In total, 1844 subjects were assigned to an experimental arm, and 1591 subjects were assigned to a placebo arm. Publication bias was ruled out by funnel plot and statistical testing (<jats:italic>P<\/jats:italic>\u2003= 0.975). In the overall analysis, the summary statistic was 0.295 (95% confidence interval: 0.208\u20130.382, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), indicating that the interventional drug has 30% excess probability of producing a response compared with placebo. The most significant source of heterogeneity was the year of publication (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The data clearly indicate that prokinetic agents are significantly more effective than placebo in the treatment of FD. Although FD is a chronic condition, efficacy was assessed over short periods. Long\u2010term randomized controlled trials are needed to confirm the effect.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04493.x","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T12:07:22Z","timestamp":1150200442000},"page":"304-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Meta\u2010analysis of the effects of prokinetic agents in patients with functional dyspepsia"],"prefix":"10.1111","volume":"22","author":[{"given":"Toru","family":"Hiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01867.x"},{"key":"e_1_2_5_3_2","first-page":"185","article-title":"Study with two prokinetics in functional dyspepsia and GORD: domperidon vs. cisapride","volume":"48","author":"Halter F","year":"1997","journal-title":"J. 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