{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:05:25Z","timestamp":1761894325385},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T00:00:00Z","timestamp":1150416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The presence of oats in gluten\u2010free diet is controversial. The aim of this work is to evaluate if different varieties of oats exert different toxicity in coeliac disease.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Three varieties of oats were tested by two <jats:italic>in vitro<\/jats:italic> assay based on the known ability of peptic\u2010tryptic digests of coeliac\u2010active proteins to agglutinate K562 cells and to disrupt lysosomes, respectively.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Avenins from the Italian variety Astra and the Australian variety Mortlook were much more active than the Australian variety Lampton. Gliadin, digested in the same way, certainly displayed more activity than all three avenins, but rice (var. Roma) did not have measurable activity.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The results indicate that some varieties of oats may be potentially harmful to individuals with coeliac disease and therefore should be excluded from the gluten\u2010free diet required to maintain good health in coeliac disease. It is important to realize that constant, small amounts of active proteins in the diet, such as certain avenins, may prevent complete recovery of the intestinal mucosa in this disease.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04512.x","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T10:50:47Z","timestamp":1150455047000},"page":"528-531","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<i>In vitro<\/i> tests indicate that certain varieties of oats may be harmful to patients with coeliac disease"],"prefix":"10.1111","volume":"22","author":[{"given":"Marco","family":"Silano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarita","family":"Dess\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"De Vincenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Cornell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24056"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.15.4712"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(92)90219-G"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007260170010"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/1025814021000003238"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(97)00341-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200411043511924"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.024"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.8.881"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010001"},{"key":"e_1_2_5_12_2","first-page":"189","article-title":"Metabolic responses to starch in oat and wheat products. 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