{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:05:19Z","timestamp":1791551119678,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Clinical trials of probiotic treatment for Crohn\u2019s disease (CD) have yielded conflicting results. This study assessed the clinical usefulness of combined probiotic and prebiotic therapy in the treatment of active CD.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Ten active CD outpatients without history of operation for CD were enrolled. Their mean (\u00b1SD) age was 27\u2003\u00b1\u20037\u2003years and the main symptoms presented were diarrhea and abdominal pain. Patients\u2019 initial therapeutic regimen of aminosalicylates and prednisolone failed to achieve remission. Patients were thus initiated on a synbiotic therapy, consisting of both probiotics (75\u2003billion colony forming units [CFU] daily) and prebiotics (psyllium 9.9\u2003g daily). Probiotics mainly comprised <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic>. Patients were free to adjust their intake of probiotics or prebiotics throughout the trial. Crohn\u2019s disease activity index (CDAI), International Organization for the Study of Inflammatory Bowel Disease (IOIBD) score and blood sample variables were evaluated and compared before and after the trial.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The duration of the trial was 13.0\u2003\u00b1\u20034.5\u2003months. By the end of therapy, each patient had taken a 45\u2003\u00b1\u200324\u2003billion CFU daily probiotic dose, with six patients taking an additional 7.9\u2003\u00b1\u20033.6\u2003g daily psyllium dose. Seven patients had improved clinical symptoms following combined probiotic and prebiotic therapy. Both CDAI and IOIBD scores were significantly reduced after therapy (255\u2013136, <jats:italic>P<\/jats:italic>\u2003=\u20030.009; 3.5\u20132.1, <jats:italic>P<\/jats:italic>\u2003=\u20030.03, respectively). Six patients had a complete response, one had a partial response, and three were non\u2010responders. Two patients were able to discontinue their prednisolone therapy, while four patients decreased their intake. There were no adverse events.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> High\u2010dose probiotic and prebiotic cotherapy can be safely and effectively used for the treatment of active CD.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04535.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T18:04:08Z","timestamp":1152554648000},"page":"1199-1204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["High dose probiotic and prebiotic cotherapy for remission induction of active Crohn\u2019s disease"],"prefix":"10.1111","volume":"22","author":[{"given":"Shunji","family":"Fujimori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tatsuguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Gudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyuki","family":"Kishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Ehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Sekita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuguhiko","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choitsu","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70492-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.3780030309"},{"key":"e_1_2_5_4_2","first-page":"328","article-title":"An antibiotic regimen for the treatment of active Crohn\u2019s disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin","volume":"91","author":"Prantera C","year":"1996","journal-title":"Am. 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