{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T19:16:58Z","timestamp":1723490218105},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) has been shown to be an important cytokine that plays a role in cell proliferation, differentiation, tissue injury repair and ulcer healing. The purpose of this pilot study was to investigate if common polymorphisms Leu10Pro, Arg25Pro and C\u2010509T within the TGF\u2010\u03b21 gene are associated with susceptibility to gastric and duodenal ulcer disease in Russians.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Blood samples from 377 unrelated patients with gastric and duodenal ulcer disease and 226 sex\u2010 and age\u2010matched healthy controls were used to determine TGF\u2010\u03b21 gene polymorphisms by polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Leu10Pro substitution in the signal peptide of TGF\u2010\u03b21 has been found to be associated with susceptibility to gastric ulcer (odds ratio [OR] 1.76, 95% confidence interval [CI] 1.12\u20132.77). A genotype combination of 10Leu\/Leu\u2003\u00d7\u200325Arg\/Arg\u2003\u00d7\u2003\u2212509C\/C was also associated with susceptibility to gastric ulcer disease (OR 1.81, <jats:italic>P<\/jats:italic>\u2003=\u20030.01). In addition, the frequency of a combination of genotypes 10Pro\/Pro\u2003\u00d7\u200325Arg\/Pro\u2003\u00d7\u2003\u2212509C\/T was statistically lower in patients with duodenal ulcer than in controls (OR 0.42, <jats:italic>P<\/jats:italic>\u2003=\u20030.05). A significant difference (<jats:italic>P<\/jats:italic>\u2003= 0.04) in the distribution of rare haplotypes of the TGF\u2010\u03b21 gene between patients with duodenal ulcer and healthy controls has been found. Polymorphism Leu10Pro was in positive linkage disequilibrium with C\u2010509T polymorphism (coefficient <jats:italic>D<\/jats:italic>\u2003=\u20030.191; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These findings indicate that the Leu10Pro and C\u2010509T polymorphisms may be involved in the modulation of expression of the TGF\u2010\u03b21 gene, and therefore a predisposition to peptic ulcer disease could be linked to particular alleles of this gene. In particular, a possible role of TGF\u2010\u03b21 in the pathogenesis of gastric ulcer disease is discussed.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04542.x","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T13:31:47Z","timestamp":1153920707000},"page":"555-564","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of common transforming growth factor beta\u20101 gene polymorphisms in gastric and duodenal ulcer disease: Pilot study"],"prefix":"10.1111","volume":"22","author":[{"given":"Alexey V","family":"Polonikov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir P","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry A","family":"Belugin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina V","family":"Khoroshaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inessa O","family":"Kolchanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariya A","family":"Solodilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita P","family":"Tutochkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A","family":"Stepchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409105354"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199701000-00002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.27.291"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02989226"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.469"},{"key":"e_1_2_5_7_2","first-page":"323","article-title":"Genetic markers for peptic ulcer. 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