{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:11:20Z","timestamp":1767928280644,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Severity prediction is difficult early in the course of acute pancreatitis. Markers of pancreatic injury, or inflammatory activation are candidate markers of severity. The aim of the present study was to assess predictive abilities of carboxypeptidase\u2010B activation peptide (CAPAP\u2010B) and soluble <jats:sc>l<\/jats:sc>\u2010selectin (sL\u2010selectin) using samples collected on admission to hospital.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients with acute pancreatitis and disease (acute abdomen) and normal controls were studied. Samples were collected at admission and daily for 5\u2003days. There were significant differences between mild and severe pancreatitis in urinary and plasma CAPAP\u2010B on admission, C\u2010reactive protein on day 3 and acute physiology and chronic health evaluation (APACHE)\u2010II scores. Prediction of severity with CAPAP\u2010B on admission was as good as with APACHE\u2010II score after 48\u2003h. Carboxypeptidase\u2010B activation peptide was not raised in disease controls. By contrast, sL\u2010selectin was lowered in all cases of acute pancreatitis, and in disease controls. There was no difference between mild and severe pancreatitis.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Urinary CAPAP\u2010B, a marker of acinar injury, can be used to predict severity of acute pancreatitis at the time of admission to hospital, but sL\u2010selectin has no value in this regard. The extent of acinar injury may be a more important early marker of severity than markers of inflammatory activation.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04550.x","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T13:31:47Z","timestamp":1153920707000},"page":"349-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Carboxypeptidase\u2010B activation peptide, a marker of pancreatic acinar injury, but not <scp>l<\/scp>\u2010selectin, a marker of neutrophil activation, predicts severity of acute pancreatitis"],"prefix":"10.1111","volume":"22","author":[{"given":"Moh\u2019d Abu","family":"Hilal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Tsiang","family":"Ung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Westlake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin D","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"issue":"2","key":"e_1_2_6_2_2","first-page":"S1","article-title":"United Kingdom guidelines for the management of acute pancreatitis. 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