{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:58:11Z","timestamp":1763456291505},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Hepatitis C virus (HCV) is predominantly transmitted by blood\u2010to\u2010blood contact, typically by sharing of needles by injecting drug users. Discarded needles could act as a vector for transmission of this infection.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Two cases of HCV seroconversion following a needle\u2010stick injury in a community setting were identified. The effects of specimen processing and storage conditions on detection of HCV RNA were assessed to provide information about the likelihood of discarded needles containing infectious HCV.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Consistent with a role for discarded needles in viral transmission, <jats:italic>in vitro<\/jats:italic> studies demonstrated that viral load declined by less than one log following storage for 24\u2003h.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> All needle\u2010stick injuries should be promptly investigated by serology and HCV\u2010PCR.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04568.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T08:29:59Z","timestamp":1155025799000},"page":"1882-1885","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Transmission of hepatitis C virus by needle\u2010stick injury in community settings"],"prefix":"10.1111","volume":"22","author":[{"given":"Paul S","family":"Haber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd","family":"Dorrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kaldor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"De Kanzow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D","family":"Rawlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2003.11.010"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1045-1056(02)00067-2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(99)00046-3"},{"key":"e_1_2_7_5_2","first-page":"150","article-title":"The stability of serum hepatitis C viral RNA in various handling and storage conditions","volume":"117","author":"Fong TL","year":"1993","journal-title":"Arch. 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